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Keywords:

  • Parkinson's disease;
  • β-glucocerebrosidase;
  • α-mannosidase;
  • β-mannosidase;
  • β-hexosaminidase

Abstract

Recent studies have shown a genetic association between glucocerebrosidase deficiencies and Parkinson's disease (PD). To further explore this issue the activity of β-glucocerebrosidase and the activities of other lysosomal enzymes, α-mannosidase, β-mannosidase, β-hexosaminidase, and β-galactosidase have been evaluated in the cerebrospinal fluid (CSF) of PD patients. The activities of α-mannosidase, β-mannosidase, β-glucocerebrosidase, and β-hexosaminidase were substantially decreased in the CSF of PD patients, while levels of β-galactosidase were essentially identical to controls. This study indicates that in PD several lysosomal hydrolases have decreased activities, further supporting a possible link between pathophysiological mechanisms underlying PD and lysosomal hydrolases. © 2007 Movement Disorder Society