PET evidence of central GABAergic changes in stiff-person syndrome

Authors

  • Daniela Perani MD,

    Corresponding author
    1. Istituto Nazionale di Neuroscienze, Vita-Salute San Raffaele University, Milan, Italy
    2. Scientific Institute San Raffaele, Department of Nuclear Medicine, Milan, Italy
    • Vita-Salute San Raffaele University, Via Olgettina 60, 20132 Milan, Italy
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  • Valentina Garibotto MD,

    1. Scientific Institute San Raffaele, Department of Nuclear Medicine, Milan, Italy
    2. Milano-Bicocca University, Department of Nuclear Medicine, Milan, Italy
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  • Andrea Panzacchi MD,

    1. Scientific Institute San Raffaele, Department of Nuclear Medicine, Milan, Italy
    2. Consiglio Nazionale delle Ricerche, Istituto di Bioimmagini e Fisiologia Molecolare, Milan, Italy
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  • Rosa Maria Moresco MSc,

    1. Scientific Institute San Raffaele, Department of Nuclear Medicine, Milan, Italy
    2. Milano-Bicocca University, Department of Nuclear Medicine, Milan, Italy
    3. Consiglio Nazionale delle Ricerche, Istituto di Bioimmagini e Fisiologia Molecolare, Milan, Italy
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  • Paola Ortelli MSc,

    1. Scientific Institute San Raffaele, Department of Nuclear Medicine, Milan, Italy
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  • Massimo Corbo MD,

    1. University of Milan Medical School, IRCCS Istituto Auxologico Italiano, Department of Neurology, Milan, Italy
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  • Ferruccio Fazio MD,

    1. Scientific Institute San Raffaele, Department of Nuclear Medicine, Milan, Italy
    2. Milano-Bicocca University, Department of Nuclear Medicine, Milan, Italy
    3. Consiglio Nazionale delle Ricerche, Istituto di Bioimmagini e Fisiologia Molecolare, Milan, Italy
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  • Franco Folli MD

    1. Division of Diabetes, Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, USA
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  • These data were presented at the 58th Meeting of the American Academy of Neurology, 2006, and published in Abstract form, Neurology, vol. 66 (S2), page A134.

Abstract

We measured expression of central nervous system GABA-A receptors with 11C-flumazenil (11C-FMZ) and PET in two subjects with stiff person syndrome (SPS). We found reduced 11C-FMZ binding potential (BP) in motor-premotor cortex, and increased 11C-FMZ BP in the cerebellar nuclei. This is the first in vivo PET evidence of central GABA-A receptors dysfunction in SPS, possibly concurring to the motor symptoms. © 2007 Movement Disorder Society

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