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Inhibitory control and spatial working memory in Parkinson's disease

Authors

  • Caroline Gurvich DPsych (Clin Neuro),

    Corresponding author
    1. Experimental Neuropsychology Research Unit, School of Psychology, Psychiatry and Psychological Medicine, Monash University, Clayton, Victoria, Australia
    2. Brain Systems Research Laboratory, The Mental Health Research Institute, Parkville, Victoria, Australia
    3. Alfred Psychiatry Research Centre, The Alfred Hospital and Monash University School of Psychology, Psychiatry and Psychological Medicine, Prahran, Victoria, Australia
    • Alfred Psychiatry Research Centre, The Alfred Hospital and Monash University School of Psychology, Psychiatry and Psychological Medicine, Prahran, Victoria 3181, Australia
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  • Nellie Georgiou-Karistianis PhD,

    1. Experimental Neuropsychology Research Unit, School of Psychology, Psychiatry and Psychological Medicine, Monash University, Clayton, Victoria, Australia
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  • Paul B. Fitzgerald MBBS, MPM, PhD, FRANZCP,

    1. Alfred Psychiatry Research Centre, The Alfred Hospital and Monash University School of Psychology, Psychiatry and Psychological Medicine, Prahran, Victoria, Australia
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  • Lyn Millist BApSci,

    1. Brain Systems Research Laboratory, The Mental Health Research Institute, Parkville, Victoria, Australia
    2. Royal Melbourne Neurosciences, Royal Melbourne Hospital, Parkville, Victoria, Australia
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  • Owen B. White MD, PhD, FRACP

    1. Experimental Neuropsychology Research Unit, School of Psychology, Psychiatry and Psychological Medicine, Monash University, Clayton, Victoria, Australia
    2. Brain Systems Research Laboratory, The Mental Health Research Institute, Parkville, Victoria, Australia
    3. Royal Melbourne Neurosciences, Royal Melbourne Hospital, Parkville, Victoria, Australia
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Abstract

Patients with Parkinson's disease (PD) have difficulty performing tasks relying on inhibitory control and working memory, functions of the prefrontal cortex. Eye movement paradigms can be used to investigate basic sensorimotor functions and higher order cognitive aspects of motor control. This study investigated inhibitory control and spatial working memory in the saccadic system of 13 individuals with mild-moderate PD and 13 age-matched controls. Tasks explored suppression of reflexive saccades during qualitatively different tasks, generation of express and anticipatory saccades, and the ability to respond to occasional, unpredictable (“oddball”) targets that occurred during a sequence of well-learned, reciprocating saccades between horizontal targets. Spatial working memory was assessed using single and two-step (involving a visually guided saccade during the delay period) memory-guided tasks. Results for the PD group indicated an increased percentage of response selection errors during an oddball task, reduced suppression of inappropriate reflexive saccades during memory-guided tasks (but not during fixation or saccade-engagement tasks), and an increased percentage of express and anticipatory saccades. Spatial working memory was preserved in the PD group during single and two-step memory-guided tasks. These findings are consistent with dysfunction within fronto-striatal and prefrontal-collicular pathways influencing suppression and selection of eye movements. © 2007 Movement Disorder Society

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