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Long lasting pure freezing of gait preceding progressive supranuclear palsy: A clinicopathological study

Authors

  • Yaroslau Compta MD,

    1. Servei de Neurologia, Institut Clínic de Neurociències, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic de Barcelona, Barcelona, Catalonia, Spain
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  • Francesc Valldeoriola MD, PhD,

    Corresponding author
    1. Servei de Neurologia, Institut Clínic de Neurociències, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic de Barcelona, Barcelona, Catalonia, Spain
    • Neurology Service, Institut Clínic de Neurociències; IDIBAPS, Hospital Clínic de Barcelona, C/Villarroel No. 170, 08036 Barcelona, Catalonia, Spain
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  • Eduardo Tolosa MD, PhD, FRCP,

    1. Servei de Neurologia, Institut Clínic de Neurociències, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic de Barcelona, Barcelona, Catalonia, Spain
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  • María Jesús Rey PhD,

    1. Banc de Teixits Neurològics, Serveis Científico-Tècnics, Universitat de Barcelona, Barcelona, Catalonia, Spain
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  • María José Martí MD, PhD,

    1. Servei de Neurologia, Institut Clínic de Neurociències, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic de Barcelona, Barcelona, Catalonia, Spain
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  • Josep Valls-Solé MD, PhD

    1. Servei de Neurologia, Institut Clínic de Neurociències, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic de Barcelona, Barcelona, Catalonia, Spain
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Abstract

Primary progressive freezing of gait (PPFG) is the term used to designate an uncommon condition featuring freezing of gait with frequent falls, without bradykinesia, rigidity or tremor, and unresponsive to levodopa. There are very few pathological reports of patients with PPFG in the literature. We report on 2 patients (one with pathological confirmation) diagnosed initially as PPFG and evolving into clinically defined progressive supranuclear palsy (PSP) more than 10 years after onset of symptoms. These 2 cases suggest that PPFG can represent the initial manifestation of a neurodegenerative disease, such as PSP, rather than a differentiated nosological entity. © 2007 Movement Disorder Society

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