Sustained relief of dystonia following cessation of deep brain stimulation

Authors

  • Matthew O. Hebb MD, PhD,

    1. Division of Neurosurgery, Department of Surgery, Dalhousie University, Halifax, Nova Scotia, Canada
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  • Paula Chiasson MSc (OT),

    1. Division of Neurosurgery, Department of Surgery, Dalhousie University, Halifax, Nova Scotia, Canada
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  • Anthony E. Lang MD,

    1. Movement Disorders Centre, Toronto Western Hospital, Toronto, Ontario, Canada
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  • Robert M. Brownstone MD, PhD,

    1. Division of Neurosurgery, Department of Surgery, Dalhousie University, Halifax, Nova Scotia, Canada
    2. Department of Anatomy and Neurobiology, Dalhousie University, Halifax, Nova Scotia, Canada
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  • Ivar Mendez MD, PhD

    Corresponding author
    1. Division of Neurosurgery, Department of Surgery, Dalhousie University, Halifax, Nova Scotia, Canada
    • Division of Neurosurgery, QEII Health Science Centre, 1796 Summer Street, Room 3807, Halifax, NS, Canada B3H 3A7
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Abstract

We describe the unusual clinical course of a patient with cranial dystonia (i.e., Meige syndrome) and additional upper limb involvement, who developed sustained relief of motor symptoms following cessation of a prolonged course of bilateral pallidal deep brain stimulation (DBS). Early response to therapy proved titratable and reversible; however, the patient gained independence from DBS in the fifth postoperative year and has since been more than a year without treatment or exacerbation of motor symptoms. Among the potential explanations for these neurological benefits lies the intriguing possibility that DBS therapy may have the capacity to induce plastic change that lessens or obviates the need for further treatment in susceptible patients. © 2007 Movement Disorder Society

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