Get access

Dopa-responsive pseudo-orthostatic tremor in parkinsonism

Authors

  • Astrid Thomas MD, PhD,

    1. Department of Oncology and Neuroscience, Neurophysiopathology, University “G. D'Annunzio” Chieti-Pescara, Italy
    2. Aging Research Center, Ce.S.I. “G. D'Annunzio” University Foundation, Chieti-Pescara, Italy
    Search for more papers by this author
  • Laura Bonanni MD, PhD,

    1. Department of Oncology and Neuroscience, Neurophysiopathology, University “G. D'Annunzio” Chieti-Pescara, Italy
    2. Aging Research Center, Ce.S.I. “G. D'Annunzio” University Foundation, Chieti-Pescara, Italy
    Search for more papers by this author
  • Angelo Antonini MD,

    1. Parkinson Institute Milan, Istituti Clinici di Perfezionamento, Milan, Italy
    Search for more papers by this author
  • Paolo Barone MD,

    1. Department of Neurological Sciences, University Federico II, Naples, Italy
    Search for more papers by this author
  • Marco Onofrj MD

    Corresponding author
    1. Department of Oncology and Neuroscience, Neurophysiopathology, University “G. D'Annunzio” Chieti-Pescara, Italy
    2. Aging Research Center, Ce.S.I. “G. D'Annunzio” University Foundation, Chieti-Pescara, Italy
    • Department of Oncology and Neuroscience, University “G. D'Annunzio” Chieti-Pescara, Neurophysiopathology, via Fonte Romana, 65124 Pescara, Italy
    Search for more papers by this author

Abstract

In four patients an inabilitating standing tremor appeared years before that parkinsonian symptoms were evidenced. This tremor was refractory to gabapentin and dramatically responded to Levodopa administration. Its dominant frequency was 6.2 to 6.9 Hz with sporadic subharmonics at 8 to 18 Hz. Three patients were affected by different genetic mutations (Park 2, Park 6, mtDNA deletion) in one no genetic or metabolic alterations could be evidenced. All patients had dopamine transporter abnormalities. We suggest that the term “Pseudo-Orthostatic Tremor” could be used to define this Dopa responsive, 6 to 7 Hz standing tremor. © 2007 Movement Disorder Society

Ancillary