Levodopa for idiopathic restless legs syndrome: Evidence-based review

Authors

  • Cristiane Fiquene Conti MD, PhD,

    1. Department of Emergency Medicine and Evidence Based Medicine, Federal University of Sao Paulo (UNIFESP), Sao Paulo, Brazil
    2. Sao Paulo Hospital Sleep Laboratory (Neuro-Sono/UNIFESP), Federal University of Sao Paulo, Sao Paulo, Brazil
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  • Márcio Moysés de Oliveira MD, PhD,

    1. Department of Emergency Medicine and Evidence Based Medicine, Federal University of Sao Paulo (UNIFESP), Sao Paulo, Brazil
    2. Sao Paulo Hospital Sleep Laboratory (Neuro-Sono/UNIFESP), Federal University of Sao Paulo, Sao Paulo, Brazil
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  • Regis Bruni Andriolo PhD,

    1. Brazilian Cochrane Center, Federal University of Sao Paulo (UNIFESP), Sao Paulo, Brazil
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  • Humberto Saconato MD, PhD,

    1. Brazilian Cochrane Center, Federal University of Sao Paulo (UNIFESP), Sao Paulo, Brazil
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  • Alvaro Nagib Atallah MD, PhD,

    1. Department of Emergency Medicine and Evidence Based Medicine, Federal University of Sao Paulo (UNIFESP), Sao Paulo, Brazil
    2. Brazilian Cochrane Center, Federal University of Sao Paulo (UNIFESP), Sao Paulo, Brazil
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  • Juliana Spelta Valbuza PhD,

    1. Department of Emergency Medicine and Evidence Based Medicine, Federal University of Sao Paulo (UNIFESP), Sao Paulo, Brazil
    2. Sao Paulo Hospital Sleep Laboratory (Neuro-Sono/UNIFESP), Federal University of Sao Paulo, Sao Paulo, Brazil
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  • Luciane Bizari Coin de Carvalho PhD,

    1. Department of Emergency Medicine and Evidence Based Medicine, Federal University of Sao Paulo (UNIFESP), Sao Paulo, Brazil
    2. Sao Paulo Hospital Sleep Laboratory (Neuro-Sono/UNIFESP), Federal University of Sao Paulo, Sao Paulo, Brazil
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  • Gilmar Fernandes do Prado MD, PhD

    Corresponding author
    1. Department of Emergency Medicine and Evidence Based Medicine, Federal University of Sao Paulo (UNIFESP), Sao Paulo, Brazil
    2. Sao Paulo Hospital Sleep Laboratory (Neuro-Sono/UNIFESP), Federal University of Sao Paulo, Sao Paulo, Brazil
    • Rua Claudio Rossi, 394 Sao Paulo – SP, CEP 01547-000, Brazil
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Abstract

Restless legs syndrome (RLS) is a sensory motor disorder characterized by a distressing urge to move the legs and sometimes also other parts of the body usually accompanied by a marked sense of discomfort or pain in the leg or other affected body part. The prevalence of RLS is estimated at 2.7 to 5% of adults and it is more common in women. The treatment of RLS with levodopa has been reported thus a systematic synthesis of evidence is necessary to evaluate the effectiveness and safety of levodopa for RLS. Systematic review of randomized or quasi-randomized, double blind trials on levodopa. Relief of restless legs symptoms marked on a validated scale, subjective sleep quality, sleep quality measured by night polysomnography and actigraphy, quality of life measured by subjective measures, adverse events associated with the treatments. Nine eligible clinical trials were included. The subjective analyses of these studies showed contradictory results, although the objective analyses showed that treatment group had a statistically significant improvement of periodic leg movement (PLM) index, favoring the treatment group. The most commonly adverse event seen was gastrointestinal symptoms. The short-term treatment with levodopa was demonstrated effective and safety for PLM, but there was only few trials assessing long-term treatment and the augmentation phenomenon in RLS. Further long-term randomized controlled trials using standard follow-up measurements as the International RLS Study Group Rating Scale are necessary. © 2007 Movement Disorder Society

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