Research Article

Validity of spiral analysis in early Parkinson's disease

  1. Rachel Saunders-Pullman MD, MPH1,2,*,
  2. Carol Derby PhD2,
  3. Kaili Stanley BS1,
  4. Alicia Floyd BA3,
  5. Susan Bressman MD1,2,
  6. Richard B. Lipton MD2,
  7. Amanda Deligtisch MD1,
  8. Lawrence Severt MD, PhD1,
  9. Qiping Yu PhD3,
  10. Mónica Kurtis MD3,
  11. Seth L. Pullman MD3

Article first published online: 11 DEC 2007

DOI: 10.1002/mds.21874

Issue

Movement Disorders

Movement Disorders

Volume 23, Issue 4, pages 531–537, 15 March 2008

Additional Information

How to Cite

Saunders-Pullman, R., Derby, C., Stanley, K., Floyd, A., Bressman, S., Lipton, R. B., Deligtisch, A., Severt, L., Yu, Q., Kurtis, M. and Pullman, S. L. (2008), Validity of spiral analysis in early Parkinson's disease. Mov. Disord., 23: 531–537. doi: 10.1002/mds.21874

Author Information

  1. 1

    Department of Neurology, Beth Israel Medical Center, New York, New York

  2. 2

    Department of Neurology, Albert Einstein College of Medicine, New York, New York

  3. 3

    Department of Neurology, Columbia University, New York, New York

*Department of Neurology, PACC, Beth Israel Medical Center, Suite 5J, 10 Union Square East, New York, NY 10003

Publication History

  1. Issue published online: 26 MAR 2008
  2. Article first published online: 11 DEC 2007
  3. Manuscript Accepted: 9 OCT 2007
  4. Manuscript Revised: 27 SEP 2007
  5. Manuscript Received: 21 AUG 2007

Funded by

  • Thomas J. Hartman Foundation for Parkinson's Disease Research
  • Marie Toulantis and William Resk
  • Joseph and Carol Reich
  • Edwin and Carolyne Levy. Grant Numbers: NIH K23 NS047256, NIH PO1 AG 03949

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Keywords:

  • Parkinson disease;
  • kinematics;
  • upper limb;
  • motor control;
  • spiral analysis

Abstract

Spiral analysis is an objective, easy to administer noninvasive test that has been proposed to measure motor dysfunction in Parkinson disease (PD). We compared overall Unified Parkinson Disease Rating Scale Part III scores to selected indices derived from spiral analysis in seventy-four patients with early PD (mean duration of disease 2.4 ± 1.7 years, mean age 61.5 ± 9.7 years). Of the spiral indices, degree of severity, first order zero crossing, second order smoothness, and mean speed were best correlated with total motor Unified Parkinson's Disease Rating Scale (UPDRS) score (all P < 0.01), and these indices showed a gradient across worsening tertiles of UPDRS (P < 0.05). Spiral indices also correlated with UPDRS ratings for the worst side and worst arm scores as well. The domains of bradykinesia, rigidity, and action tremor were correlated with first order crossing, second order smoothness, and mean speed, where as rest tremor was most highly correlated with degree of severity. This suggests that the spiral analysis may supplement motor assessment in PD, although further analysis of spiral metrics, a larger sample and longitudinal data should be evaluated. © 2007 Movement Disorder Society

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