Research Article

Executive dysfunction using behavioral assessment of the dysexecutive syndrome in Parkinson's disease†

  1. Satoshi Kamei MD1,*,
  2. Motohiko Hara MD1,
  3. Kan Serizawa MD1,
  4. Masato Murakami MD2,
  5. Tomohiko Mizutani MD1,
  6. Motoko Ishiburo PhD2,
  7. Ritsuko Kawahara PhD2,
  8. Yukiko Takagi PhD2,
  9. Katsuhiko Ogawa MD1,
  10. Hirokazu Yoshihashi MD1,
  11. Satoru Shinbo MD1,
  12. Yutaka Suzuki MD1,
  13. Mai Yamaguchi MD1,
  14. Akihiko Morita MD1,
  15. Jun Takeshita MD1,
  16. Kaname Hirayanagi MD3

Article first published online: 20 DEC 2007

DOI: 10.1002/mds.21890

Issue

Movement Disorders

Movement Disorders

Volume 23, Issue 4, pages 566–573, 15 March 2008

Additional Information

How to Cite

Kamei, S., Hara, M., Serizawa, K., Murakami, M., Mizutani, T., Ishiburo, M., Kawahara, R., Takagi, Y., Ogawa, K., Yoshihashi, H., Shinbo, S., Suzuki, Y., Yamaguchi, M., Morita, A., Takeshita, J. and Hirayanagi, K. (2008), Executive dysfunction using behavioral assessment of the dysexecutive syndrome in Parkinson's disease. Mov. Disord., 23: 566–573. doi: 10.1002/mds.21890

Author Information

  1. 1

    Division of Neurology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan

  2. 2

    Clinic of Psychosomatic Medicine, Nihon University Itabashi Hospital, Tokyo, Japan

  3. 3

    Department of Hygiene and Public Health, Nihon University of Physical Education, Tokyo, Japan

*Division of Neurology, Department of Medicine, Nihon University School of Medicine, 30–1 Oyaguchi-kamimachi, Itabashi-ku, Tokyo 173-8610, Japan

  1. †

    The authors report no conflicts of interest.

Publication History

  1. Issue published online: 26 MAR 2008
  2. Article first published online: 20 DEC 2007
  3. Manuscript Accepted: 8 NOV 2007
  4. Manuscript Revised: 3 OCT 2007
  5. Manuscript Received: 25 MAY 2007

Funded by

  • Ministry of Education, Culture, Sports, Science, and Technology of Japan for the promotion of industry–university collaboration at Nihon University, Japan
  • “Academic Frontier” Project for Private Universities (matching fund subsidy from MEXT)
  • Research Committee of CNS Degenerative Diseases
  • Ministry of Health, Labor and Welfare of Japan

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Keywords:

  • executive function;
  • Parkinson's disease;
  • predisposing factor;
  • behavioral assessment of the dysexecutive syndrome (BADS);
  • Unified Parkinson's Disease Rating Scale (UPDRS)

Abstract

The objective of this study was to evaluate the executive dysfunction (ExD) in Parkinson's disease (PD) using the Behavioral Assessment of the Dysexecutive Syndrome (BADS), which provides a wide-range assessment of ExD. The BADS and the Unified Parkinson's Disease Rating Scale (UPDRS) were investigated in 63 nondemented PD patients who revealed scores of ≥24 points on the Mini-Mental State Examination based on the DSM-IV. Multiple logistic regression analysis was performed to evaluate the predisposing factors to ExD, which was defined as <70 points on the age-controlled standardized score. The total score on the UPDRS was a significant independent predisposing factor to ExD. Among the various parts of the UPDRS, part II was the significant factor for ExD. The profile scores of all subtests on the BADS in patients with ExD were significantly lower than those of patients without ExD. All profile scores decreased with severity of PD, but the changes among these scores differed. ExD in nondemented PD predisposed to a greater severity of PD, particularly as regards the activity of daily living impairment. Nondemented PD revealed wide-range components of ExD. All components of ExD were impaired with severity of PD, but the patterns of each component exhibited variety. © 2007 Movement Disorder Society

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