Brief Report

Assessment of idiopathic rapid-eye-movement sleep behavior disorder by transcranial sonography, olfactory function test, and FP-CIT-SPECT

  1. Marcus M. Unger MD1,*,
  2. Jens C. Möller MD1,
  3. Karin Stiasny-Kolster MD1,
  4. Katharina Mankel MS1,
  5. Daniela Berg MD2,
  6. Uwe Walter MD3,
  7. Helmut Hoeffken MD4,
  8. Geert Mayer MD5,
  9. Wolfgang H. Oertel MD1

Article first published online: 3 JAN 2008

DOI: 10.1002/mds.21908

Issue

Movement Disorders

Movement Disorders

Volume 23, Issue 4, pages 596–599, 15 March 2008

Additional Information

How to Cite

Unger, M. M., Möller, J. C., Stiasny-Kolster, K., Mankel, K., Berg, D., Walter, U., Hoeffken, H., Mayer, G. and Oertel, W. H. (2008), Assessment of idiopathic rapid-eye-movement sleep behavior disorder by transcranial sonography, olfactory function test, and FP-CIT-SPECT. Mov. Disord., 23: 596–599. doi: 10.1002/mds.21908

Author Information

  1. 1

    Department of Neurology, Philipps-Universität Marburg, Germany

  2. 2

    Hertie Institute for Clinical Brain Research, Department of Neurodegenerative Diseases, University of Tuebingen, Germany

  3. 3

    Department of Neurology, University of Rostock, Germany

  4. 4

    Department of Nuclear Medicine, Philipps-Universität Marburg, Germany

  5. 5

    Hephata-Clinic for Neurology, Schwalmstadt-Treysa, Germany

*Department of Neurology, Philipps Universität Marburg, Rudolf-Bultmann-Strasse 8. 35033 Marburg, Germany

Publication History

  1. Issue published online: 26 MAR 2008
  2. Article first published online: 3 JAN 2008
  3. Manuscript Accepted: 11 NOV 2007
  4. Manuscript Revised: 8 NOV 2007
  5. Manuscript Received: 20 AUG 2007

Funded by

  • BMBF. Grant Number: 01GI0401
  • Willy und Monika Pitzer Stiftung

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Keywords:

  • Parkinson's disease;
  • rapid-eye-movement sleep behavior disorder;
  • transcranial sonography;
  • substantia nigra hyperechogenicity

Abstract

Idiopathic rapid-eye-movement (REM) sleep behavior disorder (iRBD) has been suggested to be a risk factor for subsequent development of neurodegenerative disorders, especially Parkinson's disease (PD) and other α-synucleinopathies. At present, it is not possible to predict whether or not an iRBD patient will eventually develop PD. Here, we report 5 iRBD patients who underwent a test battery comprising a neurological examination (including UPDRS rating), mini mental state examination testing, transcranial sonography, olfactory function testing, and presynaptic dopamine transporter imaging with FP-CIT-SPECT. Our preliminary data show the diverse pattern of individual combinations of pathological findings when a multimodal assessment approach is applied in this patient group. Large-size longitudinal studies in iRBD patients are required to evaluate the usefulness of diagnostic tests to identify the subgroup of iRBD patients that is prone to develop PD. © 2007 Movement Disorder Society

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