Bilateral pedunculopontine nuclei strokes presenting as freezing of gait

Authors

  • Sheng-Han Kuo MD,

    1. Department of Neurology, Parkinson's Disease Center and Movement Disorders Clinic, Baylor College of Medicine, Houston, Texas
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  • Christopher Kenney MD,

    1. Department of Neurology, Parkinson's Disease Center and Movement Disorders Clinic, Baylor College of Medicine, Houston, Texas
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  • Joseph Jankovic MD

    Corresponding author
    1. Department of Neurology, Parkinson's Disease Center and Movement Disorders Clinic, Baylor College of Medicine, Houston, Texas
    • Department of Neurology, Parkinson's Disease Center, and Movement Disorders Clinic, Baylor College of Medicine, 6550 Fannin, Suite 1801, Houston, Texas 77030
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Abstract

The penduculopontine nucleus (PPN) has been suggested to play an important role in locomotion, based on animal studies, but its function in humans has not been well defined. Autopsy studies have suggested that PPN pathology correlates with gait dysfunction in Parkinson's disease and in progressive supranuclear palsy but direct clinical evidence is lacking. We report a patient with bilateral PPN infarcts whose dominant clinical feature was freezing of gait, thus providing evidence that PPN is involved in human locomotion and that damage to the PPN may lead to abnormal gait. © 2008 Movement Disorder Society

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