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Patient and caregiver quality of life in Huntington's disease

Authors

  • Rebecca E. Ready PhD,

    Corresponding author
    1. Department of Psychology, University of Massachusetts, Amherst, Massachusetts
    • The University of Massachusetts, Department of Psychology, Tobin Hall, 135 Hicks Way, Amherst, MA 01003

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  • Melissa Mathews MA,

    1. Department of Psychology, University of Massachusetts, Amherst, Massachusetts
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  • Anne Leserman MSW, LISW,

    1. Department of Psychiatry, University of Iowa Hospital and Clinics, Iowa City, Iowa
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  • Jane S. Paulsen PhD

    1. Department of Psychiatry, University of Iowa Hospital and Clinics, Iowa City, Iowa
    2. Department of Psychology, University of Iowa, Iowa City, Iowa
    3. Department of Neurology, University of Iowa Hospital and Clinics, Iowa City, Iowa
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Abstract

Little is known about subjective perceptions of quality of life (QOL) in Huntington's disease (HD). The current study determined correlates of patient and caregiver QOL and assessed change over time. Participants were 22 patient-caregiver dyads, who rated QOL at baseline and 6 months later. Overall, patients' functional and cognitive impairment were significantly correlated with patient and caregiver QOL. Neuropsychiatric symptoms had differential impact on patient and caregiver QOL. Furthermore, when patients recalled their QOL about a previous time, their recall may have been negatively biased. Clinical implications of results are discussed. Future work is needed because subjective QOL is an important outcome measure in therapeutic trials. © 2008 Movement Disorder Society

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