Neuronal activity of the red nucleus in Parkinson's disease

Authors

  • María C. Rodriguez-Oroz MD, PhD,

    Corresponding author
    1. Department of Neurology and Neurosurgery, Clínica Universitaria and Medical School, Neuroscience Division, CIMA, University of Navarra, Pamplona, Spain, CIBERNED, Centro Investigación Biomedica en Red Enfermedades Neurodegenerativas (Spanish Government)
    • Clínica Universitaria de Navarra, Avda Pio XII 36, Pamplona 31008, Spain

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  • Manolo Rodriguez MD, PhD,

    1. Neurobiology and Experimental Neurology Laboratory, Department of Physiology, Medical School, University of La Laguna Tenerife, Spain, CIBERNED, Centro Investigación Biomedica en Red Enfermedades Neurodegenerativas (Spanish Government)
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  • Carlos Leiva MD, PhD,

    1. Neurology and Neurosurgery Department, Hospital Universitario de Alicante, Alicante, Spain
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  • Miguel Rodriguez-Palmero MD,

    1. Department of Neurology and Neurosurgery, Hospiten, Tenerife, Spain
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  • Juan Nieto MD, PhD,

    1. Neurology and Neurosurgery Department, Hospital Universitario de Alicante, Alicante, Spain
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  • David Garcia-Garcia MS,

    1. Department of Neurology and Neurosurgery, Clínica Universitaria and Medical School, Neuroscience Division, CIMA, University of Navarra, Pamplona, Spain, CIBERNED, Centro Investigación Biomedica en Red Enfermedades Neurodegenerativas (Spanish Government)
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  • Jose Luis Zubieta MD, PhD,

    1. Department of Neuroradiology, Clínica Universitaria and Medical School, University of Navarra, Pamplona, Spain
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  • Carlos Cardiel MD,

    1. Therapy Consultant, Medtronic Inc. Spain
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  • Jose A. Obeso MD, PhD

    1. Department of Neurology and Neurosurgery, Clínica Universitaria and Medical School, Neuroscience Division, CIMA, University of Navarra, Pamplona, Spain, CIBERNED, Centro Investigación Biomedica en Red Enfermedades Neurodegenerativas (Spanish Government)
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Abstract

Precise placement of the electrodes for stimulation of the subthalamic nucleus (STN) in Parkinson's disease (PD) is crucial for the therapeutic benefit. As a result of the mistargeting and misplacement of the electrodes during surgery in 2 patients with PD, we have characterized the neuronal firing in the red nucleus (RN) and observed the effects of stimulation of this nucleus. Although the neuronal firing (mean ± SD) of the RN (34 ± 4.4 Hz) resembles that described for the STN (33.1 ± 16.6 Hz), a higher proportion of cells responded to the movement of the contralateral limbs (70–80%). Stimulation in the area of the RN-induced intolerable side effects without motor improvement. We conclude that the STN and RN have some similar neurophysiological features but can be distinguished intraoperatively. This initial description of the physiological characteristics of the RN in humans will draw attention to the possibility of confusing the RN and STN during intraoperative recording. © 2008 Movement Disorder Society

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