PET study of brain acetylcholinesterase in cerebellar degenerative disorders

Authors

  • Shigeki Hirano MD,

    1. Department of Neurology, Chiba University Graduate School of Medicine, Chiba, Japan
    2. Molecular Probe Group, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
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  • Hitoshi Shinotoh MD, PhD,

    1. Molecular Probe Group, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    2. Asahi Hospital for Neurological Diseases, Chiba, Japan
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  • Kimihito Arai MD,

    1. Department of Neurology, National Hospital Organization Chiba-East Hospital, Chiba, Japan
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  • Akiyo Aotsuka MD, PhD,

    1. Molecular Probe Group, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    2. Department of Neurology, Chiba Aoba Municipal Hospital, Chiba, Japan
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  • Fumihiko Yasuno MD, PhD,

    1. Department of Psychiatry, University of Tsukuba Hospital, Ibaraki, Japan
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  • Noriko Tanaka MD, PhD,

    1. Molecular Probe Group, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    2. Department of Neurosurgery, Tokyo Women's Medical University, Medical Center East, Tokyo
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  • Tsuneyoshi Ota MD, PhD,

    1. Molecular Probe Group, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    2. Department of Psychiatry, Juntendo University School of Medicine, Tokyo
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  • Koichi Sato MD, PhD,

    1. Molecular Probe Group, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    2. Department of Psychiatry, Teikyo University School of Medicine, Ichihara Hospital, Chiba, Japan
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  • Kiyoshi Fukushi PhD,

    1. Molecular Probe Group, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
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  • Shuji Tanada MD, PhD,

    1. National Institute of Radiological Sciences, Chiba, Japan
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  • Takamichi Hattori MD,

    1. Department of Neurology, Chiba University Graduate School of Medicine, Chiba, Japan
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  • Toshiaki Irie PhD

    Corresponding author
    1. Molecular Probe Group, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    • Molecular Probe Group, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan, 4-9-1, Anagawa, Inage-ku, Chiba-shi 263-8555, Japan
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Abstract

To elucidate characteristic changes of brain acetylcholinesterase (AChE) in cerebellar degenerative disorders. Eight patients with the cerebellar variant of multiple system atrophy (MSA-C), 7 patients with spinocerebellar ataxia type-3 (SCA-3), 3 patients with SCA-6, and 13 healthy age-matched volunteers participated in this study. Brain AChE activity was measured by [11C] N-methylpiperidin-4-yl propionate PET in all subjects. Brain AChE activities were significantly decreased in the thalamus (−27%) and the posterior lobe of cerebellar cortex (−36%) in patients with MSA-C and in the thalamus (−23%) in patients with SCA-3 compared with healthy controls (P < 0.01). Thalamic AChE activities of SCA-3 patients were negatively correlated with the unified Parkinson's disease rating scale motor subscore (P < 0.001). AChE activities were not significantly altered in the cerebral cortex in any disease group. Reduction of AChE activities in the thalamus and cerebellum in MSA and in the thalamus in SCA-3 suggest that cholinergic modulating drugs may have a role in the treatment of ataxia and other symptoms in these disorders. © 2008 Movement Disorder Society

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