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Bilateral deep brain stimulation of the globus pallidus internus in tardive dystonia


  • Potential conflict of interest: None reported.


Tardive dystonia is a disabling movement disorder as a consequence of exposure to neuroleptic drugs. We followed 6 patients with medically refractory tardive dystonia treated by bilateral globus pallidus internus (GPi) deep brain stimulation (DBS) for 21 ± 18 months. At last follow-up, the Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS) motor score improved by 86% ± 14%, and the BFMDRS disability score improved by 80% ± 12%. Bilateral GPi-DBS is a beneficial therapeutic option for the long-term relief of tardive dystonia. © 2008 Movement Disorder Society

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