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Prevalence of unilateral tremor in autosomal dominant essential tremor

Authors

  • Fenna Phibbs MD,

    1. Department of Neurology, Vanderbilt University, Nashville, Tennessee; 2Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee
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  • John Y. Fang MD,

    1. Department of Neurology, Vanderbilt University, Nashville, Tennessee; 2Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee
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  • Michael K. Cooper MD,

    1. Department of Neurology, Vanderbilt University, Nashville, Tennessee; 2Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee
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  • David P. Charles MD,

    1. Department of Neurology, Vanderbilt University, Nashville, Tennessee; 2Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee
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  • Thomas L. Davis MD,

    1. Department of Neurology, Vanderbilt University, Nashville, Tennessee; 2Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee
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  • Peter Hedera MD

    Corresponding author
    1. Department of Neurology, Vanderbilt University, Nashville, Tennessee; 2Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee
    • Department of Neurology, Vanderbilt University, 465 21st Avenue South, 6140 MRB III, Nashville, TN 37232-8552, USA
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Abstract

The presence of bilateral arm tremor is a key diagnostic feature of essential tremor (ET). We analyzed the presence of unilateral arm tremor in familial ET cohort of 133 autosomal dominant ET kindreds with 412 affected individuals. Inclusion criteria in patients with unilateral arm postural and/or kinetic tremor required the duration of tremor for at least 5 years, without hypokinetic-rigid syndrome, dystonic posturing, or history of sudden onset of tremor. Only subjects with at least one living first degree relative who met diagnostic criteria for definite ET were included. Eighteen subjects met the inclusion criteria and five had postural tremor only, while the majority (13/18) had a combination of postural and kinetic tremor. Our data shows that unilateral tremor associated with ET is relatively rare and can be identified in 4.4% patients in a cohort of familial ET. © 2008 Movement Disorder Society

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