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Striatal dopamine transporter imaging correlates with depressive symptoms and tower of London task performance in Parkinson's disease

Authors

  • Irena Rektorova MD, PhD,

    Corresponding author
    1. Movement Disorders Centre, First Department of Neurology, Masaryk University, St. Anne's Teaching Hospital, Brno, Czech Republic
    • First Department of Neurology, Masaryk University and St Anne's Hospital, Pekarska 53, 656 91, Brno, Czech republic
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  • Hana Srovnalova MD,

    1. Movement Disorders Centre, First Department of Neurology, Masaryk University, St. Anne's Teaching Hospital, Brno, Czech Republic
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  • Radka Kubikova,

    1. Movement Disorders Centre, First Department of Neurology, Masaryk University, St. Anne's Teaching Hospital, Brno, Czech Republic
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  • Jiri Prasek MD, PhD

    1. Department of Nuclear Medicine, Masaryk University, Teaching Hospital Bohunice, Brno, Czech Republic
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Abstract

We studied whether the 123I-FP-CIT uptake in the striatum correlates with depressive symptoms and cognitive performance in patients with Parkinson's disease (PD). Twenty patients with PD without major depression and/or dementia (mean age 61.7 ± 12.7 years) underwent the 123I-FP-CIT SPECT. Depressive symptoms and cognitive performance were assessed in the ON state. The ratios of striatal to occipital binding for the entire striatum, putamina, and putamen to the caudate (put/caud) index were calculated in the basal ganglia. The association between neuropsychiatric measures and dopamine transporter (DAT) availability was calculated; multiple regression analysis was used to assess association with age and disease duration. We found significant correlations between Montgomery and Asberg Depression Rating Scale (MARDS) and Tower of London (TOL) task scores and 123I-FP-CIT uptake in various striatal ROIs. Multiple regression analysis confirmed the significant relationship between TOL performance and put/caud ratio (P = 0.001) and to age (P = 0.001), and between MADRS and left striatal (P = 0.005) and putaminal DAT availability (P = 0.003). Our pilot study results demonstrate that imaging with 123I-FP-CIT SPECT appears to be sensitive for detecting dopaminergic deficit associated with mild depressive symptoms and specific cognitive dysfunction in patients with PD, yet without a current depressive episode and/or dementia. © 2008 Movement Disorder Society

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