Microstructural abnormalities of striatum and thalamus in children with Tourette syndrome

Authors

  • Malek I. Makki PhD,

    Corresponding author
    1. Radiology Department, Wayne State University School of Medicine, Detroit, Michigan, USA
    2. Pediatric Neurology Department, Wayne State University School of Medicine, Detroit, Michigan, USA
    • PET Center, Children's Hospital of Michigan, 3901 Beaubien Blvd, Detroit, MI 48201, USA
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  • Michael Behen PhD,

    1. Pediatric Neurology Department, Wayne State University School of Medicine, Detroit, Michigan, USA
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  • Arpi Bhatt BS,

    1. Pediatric Neurology Department, Wayne State University School of Medicine, Detroit, Michigan, USA
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  • Benjamin Wilson BA,

    1. Pediatric Neurology Department, Wayne State University School of Medicine, Detroit, Michigan, USA
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  • Harry T. Chugani MD

    1. Pediatric Neurology Department, Wayne State University School of Medicine, Detroit, Michigan, USA
    2. PET Center, Children's Hospital of Michigan, Detroit, Michigan, USA
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  • Potential conflict of interest: None reported.

Abstract

We applied diffusion-tensor MRI (DT-MRI) to investigate directly the water diffusivity within subcortical gray matter structures comprising the fronto-striato-thalamic (FST) circuit, which is implicated in the pathophysiology of Tourette syndrome (TS). We investigated the structural integrity of basal ganglia and thalamus in 23 children with TS and 35 age-matched healthy controls (NC), and examined the association of DT-MRI measures to tic severity and comorbid symptoms. We measured parallel (λ1) and perpendicular (λ23) diffusivity, mean diffusivity (MD), and fractional anisotropy (FA) in both hemispheres. Compared with NC, the TS group showed a significant increase in λ1 (P = 0.003) and MD (P = 0.027) in the bilateral putamen, an increase in λ23 in right thalamus (P = 0.008), and a reversed asymmetry of FA (P = 0.03) in the thalamus. There was a significant positive correlation between λ23 in right thalamus and tic severity. TS patients showed significantly lower left caudate volume (P = 0.011) and bilateral thalamic volumes (left, P = 0.035, right P = 0.006) compared with NC. These findings support the notion that microstructural dysfunction measured by DT-MRI in component regions of the FST circuit contribute to the pathophysiology in TS. © 2008 Movement Disorder Society

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