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Genetic association study of the P-type ATPase ATP13A2 in late-onset Parkinson's disease

Authors

  • Aleksandar Rakovic MSc,

    1. Department of Neurology, University of Lübeck, Lübeck, Germany
    2. Department of Human Genetics, University of Lübeck, Lübeck, Germany
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    • The first two authors contributed equally to this work

  • Barbara Stiller MSc,

    1. Institute of Human Genetics, University of Cologne, Cologne, Germany
    2. Institute for Genetics, University of Cologne, Cologne, Germany
    3. Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany
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    • The first two authors contributed equally to this work

  • Ana Djarmati PhD,

    1. Department of Neurology, University of Lübeck, Lübeck, Germany
    2. Department of Human Genetics, University of Lübeck, Lübeck, Germany
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  • Antonia Flaquer MSc,

    1. Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany
    Current affiliation:
    1. Institute of Medical Biometry and Epidemiology, Philipps University, Marburg, Germany
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    • Antonia Flaquer's current affiliation: Institute of Medical Biometry and Epidemiology, Philipps University, Marburg, Germany

  • Jan Freudenberg MD,

    1. Laboratories of Neurogenetics, Department of Neurology, University of California at San Franscisco, San Francisco, California, USA
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  • Mohammad-Reza Toliat PhD,

    1. Institute for Genetics, University of Cologne, Cologne, Germany
    2. Cologne Center for Genomics, University of Cologne, Cologne, Germany
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  • Michael Linnebank MD,

    1. Department of Neurology, University of Bonn, Bonn, Germany
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  • Vladimir Kostic MD,

    1. Department of Neurology, University of Belgrade, Belgrade, Serbia
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  • Katja Lohmann PhD,

    1. Department of Neurology, University of Lübeck, Lübeck, Germany
    2. Department of Human Genetics, University of Lübeck, Lübeck, Germany
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  • Sebastian Paus MD,

    1. Department of Neurology, University of Bonn, Bonn, Germany
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  • Peter Nürnberg PhD,

    1. Institute for Genetics, University of Cologne, Cologne, Germany
    2. Cologne Center for Genomics, University of Cologne, Cologne, Germany
    3. Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECEAD), University of Cologne, Cologne, Germany
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  • Christian Kubisch MD,

    1. Institute of Human Genetics, University of Cologne, Cologne, Germany
    2. Institute for Genetics, University of Cologne, Cologne, Germany
    3. Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany
    4. Cologne Center for Genomics, University of Cologne, Cologne, Germany
    5. Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECEAD), University of Cologne, Cologne, Germany
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  • Christine Klein MD,

    1. Department of Neurology, University of Lübeck, Lübeck, Germany
    2. Department of Human Genetics, University of Lübeck, Lübeck, Germany
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  • Ullrich Wüllner MD,

    1. Department of Neurology, University of Bonn, Bonn, Germany
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  • Alfredo Ramirez MD

    Corresponding author
    1. Institute of Human Genetics, University of Cologne, Cologne, Germany
    2. Institute for Genetics, University of Cologne, Cologne, Germany
    3. Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany
    • Institute of Human Genetics, University of Cologne, Kerpener Strasse 34, 50931 Cologne, Germany

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  • Potential conflict of interest: None reported.

Abstract

A role of ATP13A2 in early-onset Parkinsonism (EOP) has been proposed. Conversely, the contribution of this ATPase to late-onset Parkinson's disease (PD) remains unexplored. We therefore conducted a case–control association study in this age-of-onset group with PD. The initial sample was of German origin and consisted of 220 patients with late-onset PD (mean age of onset 60.1 years) and 232 age-matched unrelated controls. Five single nucleotide polymorphisms (SNPs) covering ATP13A2 and its common haplotypes were genotyped. The overall association results in this sample were negative. Interestingly, gender stratification gave a positive result for SNP rs11203280 (PUNC = 0.016) in men. This result could not be reproduced in a replication sample of German and Serbian origin composed of 161 patients with late-onset PD (mean age of onset 51.7 years) and 150 age- and ethnic-matched controls. In conclusion, we found no consistent evidence for an association between ATP13A2 and late-onset PD. © 2008 Movement Disorder Society

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