Potential conflict of interest: Nothing to report.
Biopsies of olfactory epithelium in patients with Parkinson's disease†
Version of Record online: 9 FEB 2009
Copyright © 2009 Movement Disorder Society
Volume 24, Issue 6, pages 906–914, 30 April 2009
How to Cite
Witt, M., Bormann, K., Gudziol, V., Pehlke, K., Barth, K., Minovi, A., Hähner, A., Reichmann, H. and Hummel, T. (2009), Biopsies of olfactory epithelium in patients with Parkinson's disease. Mov. Disord., 24: 906–914. doi: 10.1002/mds.22464
- Issue online: 24 APR 2009
- Version of Record online: 9 FEB 2009
- Manuscript Accepted: 24 DEC 2008
- Manuscript Revised: 17 DEC 2008
- Manuscript Received: 14 NOV 2008
Additional Supporting Information may be found in the online version of this article.
|MDS_22464_sm_supptable1.doc||102K||Supporting Table 1. Survey of the participants of this study. The data in the “type” column refer to classification of olfactory epithelium (OE) in at least one of the samples, as defined in Supplemental Table 2. PD, Parkinson's disease.|
|MDS_22464_sm_supptable2.doc||54K||Supporting Table 2. Classification of olfactory epithelium.|
|MDS_22464_sm_supptable3.doc||55K||Supporting Table 3. Oligonucleotid sequences of primers used for RT-PCR.|
|MDS_22464_sm_suppfig1.tif||151K||Supporting Figure 1. Schematic view of the lateral wall of the nasal cavity. Biopsies were taken from the insertion of the medial turbinate (arrows, see also “MT” in Figure 2) and from the dorsal septum at the same level (not shown).|
|MDS_22464_sm_suppfig2.tif||748K||Supporting Figure 2. Immunohistochemical detection of α-synuclein in the olfactory mucosa of two patients with Parkinson's disease (A, #263; B, #264). There is no reactivity of α-synuclein. No counterstain in A(, haematoxylin counterstain in B. Scale bar: 50 μm.|
|MDS_22464_sm_suppfig3.tif||2977K||Supporting Figure 3. A: RT-PCR amplification of OMP mRNA in selected individuals: hyposmic patients with Parkinson's disease (265-P, 274-P), hyposmic (284, 276), anosmic (280, 273) and normosmic (278, 279) patients. Most of them showed a positive band for gene products, except patient #276. Even normosmic individuals presented relatively weak OMP bands. Patient #265-P (PD) revealed 3 positive OMP bands in different biopsy sites. B This survey illustrates the occurrence of mRNAs for several gene products associated with neurogenetic processes. mRNAs for P75NGFr, nestin, and beta-tubulin are expressed in all subjects investigated, regardless of their olfactory status.|
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