Additional Supporting Information may be found in the online version of this article.

MDS_22464_sm_suppinfo.doc43KSupplemental Methods
MDS_22464_sm_supptable1.doc102KSupporting Table 1. Survey of the participants of this study. The data in the “type” column refer to classification of olfactory epithelium (OE) in at least one of the samples, as defined in Supplemental Table 2. PD, Parkinson's disease.
MDS_22464_sm_supptable2.doc54KSupporting Table 2. Classification of olfactory epithelium.
MDS_22464_sm_supptable3.doc55KSupporting Table 3. Oligonucleotid sequences of primers used for RT-PCR.
MDS_22464_sm_suppfig1.tif151KSupporting Figure 1. Schematic view of the lateral wall of the nasal cavity. Biopsies were taken from the insertion of the medial turbinate (arrows, see also “MT” in Figure 2) and from the dorsal septum at the same level (not shown).
MDS_22464_sm_suppfig2.tif748KSupporting Figure 2. Immunohistochemical detection of α-synuclein in the olfactory mucosa of two patients with Parkinson's disease (A, #263; B, #264). There is no reactivity of α-synuclein. No counterstain in A(, haematoxylin counterstain in B. Scale bar: 50 μm.
MDS_22464_sm_suppfig3.tif2977KSupporting Figure 3. A: RT-PCR amplification of OMP mRNA in selected individuals: hyposmic patients with Parkinson's disease (265-P, 274-P), hyposmic (284, 276), anosmic (280, 273) and normosmic (278, 279) patients. Most of them showed a positive band for gene products, except patient #276. Even normosmic individuals presented relatively weak OMP bands. Patient #265-P (PD) revealed 3 positive OMP bands in different biopsy sites. B This survey illustrates the occurrence of mRNAs for several gene products associated with neurogenetic processes. mRNAs for P75NGFr, nestin, and beta-tubulin are expressed in all subjects investigated, regardless of their olfactory status.

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