Weight loss, body fat mass, and leptin in Parkinson's disease

Authors

  • Birgitta Lorefält RNT, PhD,

    Corresponding author
    1. Department of Medical and Health Sciences, Faculty of Health Sciences, Linköping University, Sweden
    2. Division of Nursing Sciences, Faculty of Health Sciences, Linköping University, Sweden
    • Department of Medical and Health Sciences, Division of Nursing Science, Faculty of Health Sciences, Linköping University, SE-581 85 Linköping, Sweden
    Search for more papers by this author
  • Göran Toss MD, PhD,

    1. Department of Medical and Health Sciences, Faculty of Health Sciences, Linköping University, Sweden
    2. Division of Internal Medicine, Faculty of Health Sciences, Linköping University, Sweden
    Search for more papers by this author
  • Ann-Kathrine Granérus MD, PhD

    1. Division of Geriatrics, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Sweden
    Search for more papers by this author

  • Potential conflict of interest: None reported.

Abstract

Weight loss is a common problem in Parkinson's disease (PD), but the causative mechanisms behind this weight loss are unclear. We compared 26 PD patients with sex and age matched healthy controls. Examinations were repeated at baseline, after one and after two years. Body fat mass was measured by Dual X-ray Absorptiometry (DXA). Seventy three per cent of the PD patients lost body weight. Loss of body fat mass constituted a considerable part of the loss of body weight. In the patients who lost weight, serum leptin levels were lower than in those who did not lose weight. The relationship between low body fat mass and low leptin levels seems to be relevant, at least for female PD patients. It is reasonable to believe that low leptin levels in these patients could be secondary to the decreased body fat mass. © 2009 Movement Disorder Society

Ancillary