No Lewy pathology in monkeys with over 10 years of severe MPTP Parkinsonism

Authors

  • Glenda Halliday PhD,

    Corresponding author
    1. Prince of Wales Medical Research Institute and School of Medical Sciences, Faculty of Medicine University of New South Wales, Sydney, Australia
    • Prince of Wales Medical Research Institute, Barker Street, Randwick, NSW 2031, Australia
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  • Maria Trinidad Herrero MD,

    1. Experimental Neuroscience, Department of Anatomy, Medical School, University of Murcia and CIBERNED, Murcia, Spain
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  • Karen Murphy BSc (Hons),

    1. Prince of Wales Medical Research Institute and School of Medical Sciences, Faculty of Medicine University of New South Wales, Sydney, Australia
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  • Heather McCann BMedSci (Path),

    1. Prince of Wales Medical Research Institute and School of Medical Sciences, Faculty of Medicine University of New South Wales, Sydney, Australia
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  • Francisco Ros-Bernal BSc,

    1. Experimental Neuroscience, Department of Anatomy, Medical School, University of Murcia and CIBERNED, Murcia, Spain
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  • Carlos Barcia PhD,

    1. Experimental Neuroscience, Department of Anatomy, Medical School, University of Murcia and CIBERNED, Murcia, Spain
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  • Hideo Mori MD,

    1. Department of Neurology, Juntendo University School of Medicine, Bunkyo-ku, Tokyo, Japan
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  • Francisco J. Blesa BSci,

    1. Department of Neurology and Neuroscience Division, Clinica Universitaria and Medical School, Neuroscience Center, CIMA and CIFA, University of Navarra and CIBERNED, Pamplona, Spain
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  • José A. Obeso MD

    1. Department of Neurology and Neuroscience Division, Clinica Universitaria and Medical School, Neuroscience Center, CIMA and CIFA, University of Navarra and CIBERNED, Pamplona, Spain
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  • Potential conflict of interest: The authors have nothing to disclose.

Abstract

The recent knowledge that 10 years after transplantation surviving human fetal neurons adopt the histopathology of Parkinson's disease suggests that Lewy body formation takes a decade to achieve. To determine whether similar histopathology occurs in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-primate models over a similar timeframe, the brains of two adult monkeys made parkinsonian in their youth with intermittent injections of MPTP were studied. Despite substantial nigral degeneration and increased α-synuclein immunoreactivity within surviving neurons, there was no evidence of Lewy body formation. This suggests that MPTP-induced oxidative stress and inflammation per se are not sufficient for Lewy body formation, or Lewy bodies are human specific. © 2009 Movement Disorder Society

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