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Nigrostriatal upregulation of 5-HT2A receptors correlates with motor dysfunction in progressive supranuclear palsy

Authors

  • Maria Stamelou MD,

    1. Institute of Neuroscience and Biophysics–Medicine (INB-3), Research Center Jülich, Jülich, Germany
    2. Department of Neurology, Philipps University, Marburg, Germany
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    • The first two authors contributed equally to this study, and the last two author's contributed equally to this study.

  • Andreas Matusch MD,

    1. Institute of Neuroscience and Biophysics–Medicine (INB-3), Research Center Jülich, Jülich, Germany
    2. Department of Neurology, Philipps University, Marburg, Germany
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    • The first two authors contributed equally to this study, and the last two author's contributed equally to this study.

  • David Elmenhorst MD,

    1. Institute of Neuroscience and Biophysics–Medicine (INB-3), Research Center Jülich, Jülich, Germany
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  • René Hurlemann MD, PhD,

    1. Department of Psychiatry, University of Bonn, Bonn, Germany
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  • Karla M. Eggert MD,

    1. Department of Neurology, Philipps University, Marburg, Germany
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  • Karl Zilles MD,

    1. Institute of Neuroscience and Biophysics–Medicine (INB-3), Research Center Jülich, Jülich, Germany
    2. C. & O. Vogt Institute for Brain Research, University of Düsseldorf, Düsseldorf, Germany
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  • Wolfgang H. Oertel MD,

    1. Department of Neurology, Philipps University, Marburg, Germany
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  • Günter U. Höglinger MD,

    Corresponding author
    1. Department of Neurology, Philipps University, Marburg, Germany
    • Department of Neurology, Philipps University, Rudolf-Bultmann Str. 8, Marburg 35039, Germany
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    • The first two authors contributed equally to this study, and the last two author's contributed equally to this study.

  • Andreas Bauer MD

    Corresponding author
    1. Institute of Neuroscience and Biophysics–Medicine (INB-3), Research Center Jülich, Jülich, Germany
    2. Department of Neurology, University of Düsseldorf, Düsseldorf, Germany
    • Institute of Neuroscience and Biophysics–Medicine (INB-3), Research Center Jülich, Jülich 52425, Germany
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    • The first two authors contributed equally to this study, and the last two author's contributed equally to this study.


  • Potential conflict of interest: None reported.

Abstract

A dysfunction of multiple neurotransmitter systems is assumed as a neurochemical basis of the akinetic-rigid syndrome of progressive supranuclear palsy (PSP). In vitro studies have produced conflicting results on the serotoninergic system in PSP. We, therefore, studied the binding potential of the serotonin 2A (5-HT2A) receptor ligand [18F]altanserin in 8 patients with clinically probable PSP and 13 healthy controls using positron emission tomography. We found an up-regulation of 5-HT2A receptors in the substantia nigra and, to a lower degree, in the striatum, while neocortical 5- HT2A receptor densities showed no changes upon partial-volume correction. Nigral and striatal receptor changes were significantly correlated with patients' scores of motor dysfunction (UPDRS III, PSP-rating scale) pointing to a functional relevance of the described findings. © 2009 Movement Disorder Society

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