Neuroanatomical substrate of visuospatial and visuoperceptual impairment in Parkinson's disease

Authors

  • Joana B. Pereira MSc,

    1. Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain
    2. Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain
    3. Centro de Investigación Biomédica en Red sobre Enfermedades, Neurodegenerativas (CIBERNED), Barcelona, Spain
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  • Carme Junqué PhD,

    Corresponding author
    1. Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain
    2. Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain
    3. Centro de Investigación Biomédica en Red sobre Enfermedades, Neurodegenerativas (CIBERNED), Barcelona, Spain
    • Departament de Psiquiatria i Psicobiologia Clínica, Universitat de Barcelona, IDIBAPS, Casanova 143, 08036 Barcelona, Spain
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  • María-Jośe Martí MD, PhD,

    1. Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain
    2. Parkinson's Disease and Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociencies, Hospital Clínic de Barcelona
    3. Centro de Investigación Biomédica en Red sobre Enfermedades, Neurodegenerativas (CIBERNED), Barcelona, Spain
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  • Blanca Ramirez-Ruiz PhD,

    1. Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain
    2. Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain
    3. Centro de Investigación Biomédica en Red sobre Enfermedades, Neurodegenerativas (CIBERNED), Barcelona, Spain
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  • Nuria Bargalló MD, PhD,

    1. Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain
    2. Centre de Diagnòstic per la Imatge Hospital Clinic de Barcelona (CDIC), Barcelona, Spain
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  • Eduardo Tolosa MD, PhD

    1. Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain
    2. Parkinson's Disease and Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociencies, Hospital Clínic de Barcelona
    3. Centro de Investigación Biomédica en Red sobre Enfermedades, Neurodegenerativas (CIBERNED), Barcelona, Spain
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  • Potential conflict of interest: None.

Abstract

To determine magnetic resonance imaging patterns of gray matter (GM) atrophy underlying visuospatial and visuoperceptual impairment in Parkinson's disease (PD), we applied voxel-based morphometry to 36 nondemented PD patients and correlated their whole brain GM density with performance on three visuospatial and visuoperceptual tests. In addition, group comparisons between patients and 20 healthy controls were also performed. Correlations between visuospatial performance and GM density were found in the superior parietal lobules and the superior occipital gyrus of PD patients. Poor performance on visuoperceptual tests was also found to be significantly associated with GM decreases in the fusiform, the parahippocampus, and the middle occipital gyrus. Finally, group comparisons between controls and patients showed widespread GM cortical reductions in PD, involving posterior temporal and parietal regions. Taken together, these findings suggest that visuospatial and visuoperceptual dysfunctions reflect structural GM changes in temporo-parietal cortical regions of PD patients. © 2009 Movement Disorder Society

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