• Please log in or register to access this feature.

Research Article

Cerebellar involvement in progressive supranuclear palsy: A clinicopathological study†

  1. Masato Kanazawa MD1,
  2. Takayoshi Shimohata MD, PhD1,*,
  3. Yasuko Toyoshima MD, PhD2,
  4. Mari Tada MD1,2,
  5. Akiyoshi Kakita MD, PhD2,3,
  6. Takashi Morita MD, PhD4,
  7. Tetsutaro Ozawa MD, PhD1,
  8. Hitoshi Takahashi MD, PhD2,
  9. Masatoyo Nishizawa MD, PhD1

Article first published online: 1 MAY 2009

DOI: 10.1002/mds.22583

Issue

Movement Disorders

Movement Disorders

Volume 24, Issue 9, pages 1312–1318, 15 July 2009

Additional Information

How to Cite

Kanazawa, M., Shimohata, T., Toyoshima, Y., Tada, M., Kakita, A., Morita, T., Ozawa, T., Takahashi, H. and Nishizawa, M. (2009), Cerebellar involvement in progressive supranuclear palsy: A clinicopathological study. Mov. Disord., 24: 1312–1318. doi: 10.1002/mds.22583

Author Information

  1. 1

    Department of Neurology, Brain Research Institute, Niigata University, Niigata, Japan

  2. 2

    Department of Pathology, Brain Research Institute, Niigata University, Niigata, Japan

  3. 3

    Department of Pathological Neuroscience, Resource Branch for Brain Disease Research CBBR, Brain Research Institute, Niigata University, Niigata, Japan

  4. 4

    Department of Pathology, Shinrakuen Hospital, Niigata, Japan

*Department of Neurology, Brain Research Institute, Niigata University, 1-757 Asahimachi-dori, Chuoku, Niigata, Niigata 951-8585, Japan

  1. †

    Potential conflict of interest: Nothing to report.

Publication History

  1. Issue published online: 24 JUL 2009
  2. Article first published online: 1 MAY 2009
  3. Manuscript Accepted: 9 MAR 2009
  4. Manuscript Revised: 25 DEC 2008
  5. Manuscript Received: 24 SEP 2008

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article (HTML) Get PDF (203K)

Keywords:

  • progressive supranuclear palsy;
  • spinocerebellar ataxias;
  • Parkinson's disease;
  • parkinsonian disorders

Abstract

The clinical heterogeneity of progressive supranuclear palsy (PSP), which is classified as classic Richardson's syndrome (RS) and PSP-Parkinsonism (PSP-P), has been previously discussed. We retrospectively analyzed 22 consecutive Japanese patients with pathologically proven PSP to investigate the clinicopathological heterogeneity. We investigated the clinical features both early in and at any time during the disease course. The pathological severities of neuronal loss with gliosis and tau pathology were also evaluated. On the basis of the clinical features, 10 patients were categorized as having RS, and 8 were categorized as having PSP-P. Four patients presenting with cerebellar ataxia or cerebral cortical signs were categorized as having unclassifiable PSP. Among them, 3 developed cerebellar ataxia as the initial and principal symptom. Notably, tau-positive inclusion bodies in Purkinje cells were significantly more frequently observed in the patients with cerebellar ataxia than in those without cerebellar ataxia. All the patients with cerebellar ataxia exhibited more neuronal loss with gliosis and higher densities of coiled bodies in the cerebellar dentate nucleus than those without cerebellar ataxia. This study confirms the wide spectrum of clinicopathological manifestations associated with PSP regardless of different ethnic origin, and demonstrates that PSP patients manifest cerebellar ataxia. © 2009 Movement Disorder Society

View Full Article (HTML) Get PDF (203K)