Potential conflict of interest: Matthew Menza, MD received research support from National Institutes of Health (NINDS), Astra-Zeneca, Bristol-Myers Squibb, Boehringer Ingelheim, Forest Laboratories, GlaxoSmithKline, Lilly, Pfizer, Sanofi-Aventis, Sepracor, Takeda Wyeth and is a consultant for National Institutes of Health (NIMH, NINDS), GlaxoSmithKline, Kyowa, Labopharm, Lilly Research Laboratories, Pfizer, Sepracor, Takeda. Roseanne DeFronzo Dobkin, PhD received research support from National Institutes of Health (NINDS). Humberto Marin, MD received research support from National Institutes of Health (NINDS), GlaxoSmithKline, Lilly, Sanofi-Aventis, Sepracor, Takeda and is a consultant for Lilly Research Laboratories. Margery Mark, MD received research support from Kyowa, Cephaon and is a speaker for Allergan, Boehringer Ingelheim, GlaxoSmithKline, Valeant. Steven Buyske, PhD received research support from National Institutes of Health (NIAAA).
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Research Article
The impact of treatment of depression on quality of life, disability and relapse in patients with Parkinson's disease†
Article first published online: 1 MAY 2009
DOI: 10.1002/mds.22586
Copyright © 2009 Movement Disorder Society
Additional Information
How to Cite
Menza, M., Dobkin, R. D., Marin, H., Mark, M. H., Gara, M., Buyske, S., Bienfait, K. and Dicke, A. (2009), The impact of treatment of depression on quality of life, disability and relapse in patients with Parkinson's disease. Mov. Disord., 24: 1325–1332. doi: 10.1002/mds.22586
- †
Publication History
- Issue published online: 24 JUL 2009
- Article first published online: 1 MAY 2009
- Manuscript Accepted: 11 MAR 2009
- Manuscript Revised: 23 FEB 2009
- Manuscript Received: 10 NOV 2008
Funded by
- National Institute of Neurologic Disorders and Stroke (NINDS). Grant Number: RO1NS043144
- GlaxoSmithKline
- Clinical Trials Registration: Clintrials.gov Identifier. Grant Number: NCT 00062738
- Abstract
- Article
- References
- Cited By
Keywords:
- Parkinson's disease;
- depression;
- quality of life;
- relapse;
- antidepressants
Abstract
Parkinson's disease (PD) is a common neurodegenerative disease affecting up to one million individuals in the United States. Depression is found in 40 to 50% of these patients and is associated with a variety of poor outcomes for both patients and their families. Despite this, there are few evidence-based data to guide clinical care. This was an NIH-funded, randomized, controlled trial of paroxetine, nortriptyline, and placebo. It included an 8 week acute phase and a 16 week blind extension phase. This report details the impact of depression treatment on quality of life (QoL) and disability in the acute and extension phase of this study. Secondary outcomes included relapse, tolerability, safety, and the impact of depression treatment on PD physical functioning. Patients who had improvement in depression, compared with those who did not, had significant gains in measures of QoL and disability (PDQ-8, P = 0.0001; SF-36, P = 0.0001) at 8 weeks and maintained their gains in the extension phase. Patients who were on active drug were significantly less likely to relapse in the extension phase than those on placebo (P = 0.041). Though relatively modest in size, this trial provides the first controlled data on the impact of treatment of depression on QoL and disability in PD. It suggests that successfully treating depression in PD leads to important, sustained improvements in these outcomes and that patients who improve on antidepressants are less likely to relapse than are patients who initially improve on placebo. © 2009 Movement Disorder Society