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Neuropathology of Parkinson's disease with the R1441G mutation in LRRK2


  • Potential conflict of interest: We have received grants in the last two years from Madrilenian Mutual foundation (MMA), Department of Health of the Basque Government, “Fondo de Investigaciones Sanitarias” of the Government of Spain (FIS), and Foundation Ramon Areces to support our research on Parkinson's disease. The results of this study are not interfered by the aid received.


We report the neuropathological findings in a patient with Parkinson's disease (PD) associated with Basque R1441G-LRRK2/dardarin mutation. The patient was a man with disease onset at 68 years of age, with unilateral rest tremor; the Parkinsonism was well controlled with medication for 15 years. He died at the age of 86, after 18 years of evolution. The neuropathological examination disclosed mild neuronal loss in the substantia nigra pars compacta without α-synuclein, tau, LRRK2, or ubiquitin cytoplasmic inclusions. Lewy bodies and Lewy neurites were absent. This is the first neuropathological study of PD associated with brain with the R1441G mutation in LRRK2. © 2009 Movement Disorder Society