Association of DRD3 and GRIN2B with impulse control and related behaviors in Parkinson's disease

Authors

  • Jee-Young Lee MD,

    1. Department of Neurology, Inje University Ilsan Paik Hospital, Goyang, Korea
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  • Eun Kyung Lee RN,

    1. Clinical Research Institute and Movement Disorders Center, Seoul National University Hospital, Seoul, Korea
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  • Sung Sup Park MD, PhD,

    1. Clinical Research Institute and Movement Disorders Center, Seoul National University Hospital, Seoul, Korea
    2. Department of Laboratory Medicine, Seoul National University Hospital, Seoul, Korea
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  • Ji-Yeon Lim BS,

    1. Clinical Research Institute and Movement Disorders Center, Seoul National University Hospital, Seoul, Korea
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  • Hee Jin Kim MD,

    1. Clinical Research Institute and Movement Disorders Center, Seoul National University Hospital, Seoul, Korea
    2. Department of Neurology, Seoul National University Hospital, Seoul, Korea
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  • Ji Sun Kim MD,

    1. Department of Neurology, Seoul National University Bundang Hospital, Seongnam, Korea
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  • Beom S Jeon MD, PhD

    Corresponding author
    1. Clinical Research Institute and Movement Disorders Center, Seoul National University Hospital, Seoul, Korea
    2. Department of Neurology, Seoul National University Hospital, Seoul, Korea
    3. Neuroscience Research Institute, College of Medicine, Seoul National University, Seoul, Korea
    • Department of Neurology, Clinical Research Institute and Movement Disorders Center, Seoul National University Hospital, Seoul 110-744, Korea
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  • Potential conflict of interest: nothing to report.

Abstract

We aimed to assess whether allelic variants of dopamine receptor, glutamate receptor, and serotonin transporter genes are associated with the appearance of impulse control and related behaviors (ICRB) in Parkinson's disease (PD) with dopamine replacement therapy (DRT). We surveyed ICRB in consecutive Korean patients with PD who were treated with stable DRT using modified Minnesota Impulsive Disorders Interview over a period of 4 months. In the 404 patients who completed the interview and the 559 Korean healthy normal controls, genotyping was performed for variants of the DRD3 p.S9G, DRD2Taq1A, GRIN2B c.366C>G, c.2664C>T and c.-200T>G, and the promoter region of the serotonin transporter gene (5-HTTLPR). Behavioral abnormalities suggestive of ICRB including compulsive buying, gambling, sexual behavior and eating, and punding, were present in 14.4% of the patients. Variants of DRD2 and 5-HTTLPR were not associated with the risk of developing ICRB. However, the AA genotype of DRD3 p.S9G and the CC genotype of GRIN2B c.366C>G were more frequent in patients with ICRB than in nonaffected patients (odds ratio [OR] = 2.21, P = 0.0094; and 2.14, P = 0.0087, after adjusting for age and sex). After controlling for clinical variables in the multivariate analysis, carriage of either AA genotype of DRD3 or CC genotype of GRIN2B was identified as an independent risk factor for ICRB (adjusted OR: 2.57, P = 0.0087). Variants of DRD3 p.S9G and GRIN2B c.366C>G may be associated with the appearance of ICRB in PD. © 2009 Movement Disorder Society

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