Protein degradation, aggregation, and misfolding

Authors

  • Ana Maria Cuervo MD, PhD,

    Corresponding author
    1. Departments of Developmental and Molecular Biology and of Anatomy and Structural Biology, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, New York, USA
    • Department of Developmental and Molecular Biology, Ullmann Building Room 611, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461
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  • Esther S.P. Wong PhD,

    1. Departments of Developmental and Molecular Biology and of Anatomy and Structural Biology, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, New York, USA
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  • Marta Martinez-Vicente PhD

    1. Departments of Developmental and Molecular Biology and of Anatomy and Structural Biology, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, New York, USA
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  • Potential conflict of interest: None reported.

Abstract

The cellular surveillance systems guarantee proper removal of altered components from inside cells. Alterations of these systems in neurons have been proposed to be involved in the pathogenesis of different neurodegenerative disorders. In this review, we comment on the advances in our current understanding of how changes in the intracellular proteolytic systems, the main components of the cellular quality control system, contribute to neurodegeneration, with special emphasis on Parkinson's disease. © 2010 Movement Disorder Society

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