Gray matter correlations of cognition in incident Parkinson's disease

Authors

  • Turi O. Dalaker MD,

    Corresponding author
    1. Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, Buffalo, New York, USA
    2. Department of Radiology, Stavanger University Hospital, Stavanger, Norway
    3. The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway
    • Department of Radiology, Stavanger University Hospital, P.O. Box 8100, N-4068 Stavanger, Norway
    Search for more papers by this author
  • Robert Zivadinov MD, PhD,

    1. Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, Buffalo, New York, USA
    2. Department of Neurology, The Jacobs Neurological Institute, State University of New York at Buffalo, Buffalo, New York, USA
    Search for more papers by this author
  • Jan P. Larsen MD, PhD,

    1. The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway
    2. Department of Neurology, Stavanger University Hospital, Stavanger, Norway
    3. Institute of Clinical Medicine, University of Bergen, Bergen, Norway
    Search for more papers by this author
  • Mona K. Beyer MD, PhD,

    1. Department of Radiology, Stavanger University Hospital, Stavanger, Norway
    2. The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway
    Search for more papers by this author
  • Jennifer L. Cox PhD,

    1. Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, Buffalo, New York, USA
    2. Department of Neurology, The Jacobs Neurological Institute, State University of New York at Buffalo, Buffalo, New York, USA
    Search for more papers by this author
  • Guido Alves MD, PhD,

    1. The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway
    2. Department of Neurology, Stavanger University Hospital, Stavanger, Norway
    Search for more papers by this author
  • Kolbjorn Bronnick PhD,

    1. The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway
    Search for more papers by this author
  • Ole-Bjorn Tysnes MD, PhD,

    1. Institute of Clinical Medicine, University of Bergen, Bergen, Norway
    2. Department of Neurology, Haukeland University Hospital, Bergen, Norway
    Search for more papers by this author
  • Ronald Antulov MD,

    1. Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, Buffalo, New York, USA
    2. Department of Radiology, Clinical Hospital Centre Rijeka, Rijeka, Croatia
    Search for more papers by this author
  • Michael G. Dwyer,

    1. Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, Buffalo, New York, USA
    Search for more papers by this author
  • Dag Aarsland MD, PhD

    1. The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway
    2. Institute of Clinical Medicine, University of Bergen, Bergen, Norway
    Search for more papers by this author

  • Potential conflict of interest: Nothing to report.

Abstract

We aimed to investigate whether mild cognitive impairment (MCI) in Parkinson's disease (PD) is characterized by region-specific gray matter (GM) atrophy and to explore correlations between GM and cognition in PD. Magnetic resonance images of 42 newly diagnosed PD patients (of which 11 had MCI) and 37 normal controls were analyzed using voxel-based morphometry. Analyses comparing groups showed no regional atrophy, and in patients there were no significant correlations between cognitive domain test performance and GM loss. In conclusion, GM atrophy does not seem to be a major feature of cognitive dysfunction in incident PD. © 2010 Movement Disorder Society

Ancillary