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LINGO1 polymorphisms are associated with essential tremor in Europeans

Authors

  • Sandra Thier MSc,

    1. Department of Neurology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany
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    • The first two authors contributed equally to this work.

  • Delia Lorenz MD,

    1. Department of Neurology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany
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    • The first two authors contributed equally to this work.

  • Michael Nothnagel PhD,

    1. Institute of Medical Informatics and Statistics, Christian-Albrechts-University Kiel, Germany
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  • Giovanni Stevanin PhD,

    1. Department of Genetics and Cytogenetics, AP-HP, Pitié-Salpêtrière Hospital, Paris, France
    2. INSERM, U975, Paris, France
    3. Université Pierre et Marie Curie-Paris 6, UMR_S975, CNRS7225, Centre de Recherche Insitut du Cerveau et de la Moelle, Pitié-Salpêtrière Hospital, Paris, France
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  • Alexandra Dürr MD, PhD,

    1. Department of Genetics and Cytogenetics, AP-HP, Pitié-Salpêtrière Hospital, Paris, France
    2. INSERM, U975, Paris, France
    3. Université Pierre et Marie Curie-Paris 6, UMR_S975, CNRS7225, Centre de Recherche Insitut du Cerveau et de la Moelle, Pitié-Salpêtrière Hospital, Paris, France
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  • Almut Nebel PhD,

    1. Institute of Clinical Molecular Biology, Christian-Albrechts-University Kiel, Germany
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  • Stefan Schreiber MD,

    1. Institute of Clinical Molecular Biology, Christian-Albrechts-University Kiel, Germany
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  • Gregor Kuhlenbäumer MD, PhD,

    1. Institute of Experimental Medicine, Christian-Albrechts-University, Kiel, Germany
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  • Günther Deuschl MD, PhD,

    Corresponding author
    1. Department of Neurology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany
    • Department of Neurology, University Hospital Schleswig-Holstein, Campus Kiel, Arnold-Heller-Str. 3, Haus 41, 24105 Kiel, Germany
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    • The last two authors contributed equally as senior authors to this work.

  • Stephan Klebe MD

    1. Department of Neurology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany
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    • The last two authors contributed equally as senior authors to this work.


  • Potential confict of interest: Nothing to report.

Abstract

Essential tremor (ET) is one of the most common movement disorders. Former association studies focussing on candidate genes in ET found a number of risk variants but most of them were not replicated. Recently, a genome-wide association study revealed two intronic sequence variants in the LINGO1 gene associated with ET. Here, we have confirmed association between sequence variants in the LINGO1 gene and the ET phenotype in independent German and French ET samples. The odds ratios for the identified intronic markers rs8030859 (P = 1.0×10−4), rs9652490 (P = 9.1×10−4), and rs11856808 (P = 3.6×10−2) were 1.72 (CI 1.31-2.26), 1.61 (CI 1.21-2.14), and 1.30 (CI 1.02-1.66), respectively, in our German sample. LINGO1 is an interesting candidate gene because it plays a key role in central nervous system biology, is selectively expressed in the nervous system, and is an inhibitor of oligodendrocyte differentiation and neuronal myelination. Our study gives further evidence that LINGO1 acts as a susceptibility gene for ET. © 2010 Movement Disorder Society

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