Research Article

Safety and efficacy of perampanel in advanced Parkinson's disease: A randomized, placebo-controlled study†

  1. Karla Eggert MD1,
  2. David Squillacote MD2,
  3. Paolo Barone MD3,
  4. Richard Dodel MD4,
  5. Regina Katzenschlager MD5,
  6. Murat Emre MD6,
  7. Andrew J. Lees MD7,
  8. Olivier Rascol MD, PhD8,9,
  9. Werner Poewe MD10,
  10. Eduardo Tolosa MD11,
  11. Claudia Trenkwalder MD12,
  12. Marco Onofrj MD13,
  13. Fabrizio Stocchi MD, PhD14,
  14. Giuseppe Nappi MD15,16,
  15. Vladimir Kostic MD17,
  16. Jagoda Potic MD18,
  17. Evzen Ruzicka MD, DSc19,
  18. Wolfgang Oertel MD1,*,
  19. and in cooperation with the German Competence Network on Parkinson's Disease

Article first published online: 29 MAR 2010

DOI: 10.1002/mds.22974

Issue

Movement Disorders

Movement Disorders

Volume 25, Issue 7, pages 896–905, 15 May 2010

Additional Information

How to Cite

Eggert, K., Squillacote, D., Barone, P., Dodel, R., Katzenschlager, R., Emre, M., Lees, A. J., Rascol, O., Poewe, W., Tolosa, E., Trenkwalder, C., Onofrj, M., Stocchi, F., Nappi, G., Kostic, V., Potic, J., Ruzicka, E., Oertel, W. and and in cooperation with the German Competence Network on Parkinson's Disease (2010), Safety and efficacy of perampanel in advanced Parkinson's disease: A randomized, placebo-controlled study. Mov. Disord., 25: 896–905. doi: 10.1002/mds.22974

Author Information

  1. 1

    German Competence Network on Parkinson's Disease, Department of Neurology, Philipps-University Marburg, Marburg, Germany

  2. 2

    Eisai Global Clinical Development, Eisai Medical Research Inc., Woodcliff Lake, New Jersey, USA

  3. 3

    Department of Neurological Sciences, University of Naples Federico II-IDC Hermitage-Capodimonte, Naples, Italy

  4. 4

    Department of Neurology, Rheinische Friedrich-Wilhelms-University, Bonn, Germany

  5. 5

    Department of Neurology, Donauspital, Vienna, Austria

  6. 6

    Department of Neurology, Istanbul Medical School, Istanbul, Turkey

  7. 7

    Reta Lila Weston Institute of Neurological Studies, University College London, London, United Kingdom

  8. 8

    Clinical Investigation Center, INSERM CIC9302, University Hospital Toulouse, Toulouse, France

  9. 9

    Departments of Clinical Pharmacology and Neurosciences, INSERM UMR825, University Hospital Toulouse, Toulouse, France

  10. 10

    Department of Neurology, Medical University Innsbruck, Innsbruck, Austria

  11. 11

    Neurology Service, Hospital Clinic, Universitat de Barcelona, CIBERNED, Barcelona, Spain

  12. 12

    Paracelsus-Elena Klinik, Kassel, Germany

  13. 13

    Clinica Neurologica, Università Chieti-Pescara, Italy

  14. 14

    Department of Neurology, IRCCS San Raffaele, Rome, Italy

  15. 15

    Chair of Neurology, University “La Sapienza,” Rome, Italy

  16. 16

    IRCCS “C. Mondino Institute of Neurology” Foundation, Pavia, Italy

  17. 17

    Institute of Neurology, Clinical Centre of Serbia, Belgrade, Serbia

  18. 18

    Clinic for Neurology and Psychiatry, Clinical Hospital Centre “Zvezdara,” Belgrade, Serbia

  19. 19

    Department of Neurology, Charles University in Prague, 1st Faculty of Medicine and General Teaching Hospital, Prague, Czech Republic

*German Competence Network on Parkinson's Disease, Department of Neurology, Philipps-University Marburg, Rudolf-Bultmann-Str. 8, D-35033 Marburg, Germany

  1. †

    Potential conflict of interest: This study and editorial support were sponsored by Eisai Co., Ltd. No compensation was provided to the authors for their work on this manuscript. All authors, except for Dr. Squillacote, received compensation from Eisai for their site's conduct of the study. Drs. Barone, Lees, and Oertel received honoraria from Eisai as members of the Advisory Board of this study. Dr. Rascol has received unrestricted scientific grant and honoraria from Eisai for his advice to the company on this project. Dr. Dodel received honoraria from Eisai for presenting the study at meetings. Drs. Katzenschlager, Poewe, Kostic, and Ruzicka received honoraria from Eisai for consulting in relation to this study. Dr. Emre has been on the Protocol Development and Advisory Committee for the study and received honoraria for his advice. Dr. Onofrj received honoraria from Eisai in his capacity as Principal Investigator.

Publication History

  1. Issue published online: 5 MAY 2010
  2. Article first published online: 29 MAR 2010
  3. Manuscript Accepted: 20 NOV 2009
  4. Manuscript Revised: 19 NOV 2009
  5. Manuscript Received: 3 FEB 2009

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