Thalamic single-unit and local field potential activity in Tourette syndrome

Authors

  • Sara Marceglia PhD,

    1. Centro Clinico per le Neuronanotecnologie e la Neurostimolazione, Fondazione IRCCS Ospedale Maggiore, Policlinico, Mangiagalli e Regina Elena, Università di Milano, Milano, Italy
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  • Domenico Servello MD,

    1. Functional Neurosurgery-Tourette Clinic IRCCS Galeazzi Hospital, Milan, Italy
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  • Guglielmo Foffani PhD,

    1. School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, Pennsylvania, USA
    2. Hospital Nacional de Parapléjicos, SESCAM, Toledo, Spain
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  • Mauro Porta MD,

    1. Functional Neurosurgery-Tourette Clinic IRCCS Galeazzi Hospital, Milan, Italy
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  • Marco Sassi MD,

    1. Functional Neurosurgery-Tourette Clinic IRCCS Galeazzi Hospital, Milan, Italy
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  • Simona Mrakic-Sposta MS,

    1. Centro Clinico per le Neuronanotecnologie e la Neurostimolazione, Fondazione IRCCS Ospedale Maggiore, Policlinico, Mangiagalli e Regina Elena, Università di Milano, Milano, Italy
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  • Manuela Rosa MS,

    1. Centro Clinico per le Neuronanotecnologie e la Neurostimolazione, Fondazione IRCCS Ospedale Maggiore, Policlinico, Mangiagalli e Regina Elena, Università di Milano, Milano, Italy
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  • Sergio Barbieri MD,

    1. Centro Clinico per le Neuronanotecnologie e la Neurostimolazione, Fondazione IRCCS Ospedale Maggiore, Policlinico, Mangiagalli e Regina Elena, Università di Milano, Milano, Italy
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  • Alberto Priori MD, PhD

    Corresponding author
    1. Centro Clinico per le Neuronanotecnologie e la Neurostimolazione, Fondazione IRCCS Ospedale Maggiore, Policlinico, Mangiagalli e Regina Elena, Università di Milano, Milano, Italy
    • Clinical Center for Neuronanotechnology and Neurostimulation, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli, Regina Elena, Padiglione Monteggia or Department of Neurological Sciences, University of Milan, Via Francesco Sforza 35, 20122 Milano, Italy===

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  • Potential conflict of interest: None.

Abstract

Deep brain stimulation (DBS) of the ventralis oralis (VO) complex of the thalamus improves tics in patients with Tourette syndrome (TS). To neurophysiologically describe the VO complex we recorded, in seven patients with TS undergoing DBS electrode implantation, single-unit activity during surgery and local field potentials (LFPs) a few days after surgery. Single unit recordings showed that the VO complex is characterized by a localized pattern of bursting neuronal activity. LFP spectra demonstrated that VO of TS patients has a prominent oscillatory activity at low frequencies (2–7 Hz) and in the α-band (8–13 Hz), and a virtually absent beta activity. In each patient, the main LFP frequency significantly correlated with single-unit interburst frequency. In conclusion, we observed an oscillatory bursting activity in the VO as target region in patients with severe TS undergoing DBS surgery. © 2010 Movement Disorder Society

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