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Long-term effect of unilateral pallidotomy on levodopa-induced dyskinesia

Authors

  • Galit Kleiner-Fisman MD, FRCPC,

    Corresponding author
    1. Morton and Gloria Shulman Movement Disorders Center, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
    2. Baycrest Geriatric Hospital, University of Toronto, Toronto, Ontario, Canada
    • Morton and Gloria Shulman Movement Disorders Center, Toronto Western Hospital, University of Toronto, 399 Bathurst Street, McL-7, Toronto, Ontario, M5T 2S8 Canada

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  • Andres Lozano MD, PhD, FRCPS,

    1. Department of Neurosurgery, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
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  • Elena Moro MD, PhD,

    1. Morton and Gloria Shulman Movement Disorders Center, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
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  • Yu-Yan Poon RN,

    1. Morton and Gloria Shulman Movement Disorders Center, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
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  • Anthony E. Lang MD, FRCPC

    1. Morton and Gloria Shulman Movement Disorders Center, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
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  • Potential conflict of interest: None reported.

Abstract

Unilateral pallidotomy has been effectively used to treat parkinsonism and reduce levodopa induced dyskinesia (LID). We sought to determine the long-term effects of pallidotomy on LID in 10 patients who had initial benefit from pallidotomy but went on to require DBS surgery for symptom progression. The Dyskinesia Rating Scale (DRS) was used to rate and quantify LID in a blinded fashion. Though sample size was small, there was a trend towards a reduction in LID lasting up to 12 years suggesting that posteroventral pallidotomy may provide sustained benefit in reducing LID. © 2010 Movement Disorder Society

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