Potential conflict of interest: None.
LRRK2 variation and Parkinson's disease in African Americans†
Version of Record online: 28 JUL 2010
Published 2010 Wiley-Liss, Inc.
Volume 25, Issue 12, pages 1973–1976, 15 September 2010
How to Cite
Ross, O. A., Wilhoite, G. J., Bacon, J. A., Soto-Ortolaza, A., Kachergus, J., Cobb, S. A., Puschmann, A., Vilariño-Güell, C., Farrer, M. J., Graff-Radford, N., Meschia, J. F. and Wszolek, Z. K. (2010), LRRK2 variation and Parkinson's disease in African Americans. Mov. Disord., 25: 1973–1976. doi: 10.1002/mds.23163
- Issue online: 8 SEP 2010
- Version of Record online: 28 JUL 2010
- Manuscript Accepted: 17 MAR 2010
- Manuscript Revised: 19 FEB 2010
- Manuscript Received: 13 OCT 2009
- The Michael J. Fox foundation
- NIH. Grant Numbers: P01 AG017216, R01 NS057567, R01 AG015866, CIHR 121849, PARF C06-01
- leucine-rich repeat kinase 2;
The global impact of LRRK2 mutations is yet to be realized with a lack of studies in specific ethnic groups, including those of Asian and African descent. Herein, we investigated the frequency of common LRRK2 variants by complete exon sequencing in a series of publicly available African American Parkinson's disease patients. Our study identified three novel synonymous exonic variants and 13 known coding variations; however, there did not appear to be any frequent (>5%) pathogenic mutations. Given the ethnic-specific LRRK2 variation previously identified in PD further studies in under-represented populations are warranted. © 2010 Movement Disorder Society.