Deep brain stimulation for essential tremor: A systematic review

Authors

  • Eliana Della Flora BMedPharmBiotech (Hons), GCPH,

    1. Australian Safety and Efficacy Register of New Interventional Procedures-Surgical (ASERNIP-S), Royal Australasian College of Surgeons, Stepney, South Australia, Australia
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  • Caryn L. Perera BA (Lib Info Mgt), Grad Cert EBP,

    1. Australian Safety and Efficacy Register of New Interventional Procedures-Surgical (ASERNIP-S), Royal Australasian College of Surgeons, Stepney, South Australia, Australia
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  • Alun L. Cameron BSc (Hons), PhD,

    1. Australian Safety and Efficacy Register of New Interventional Procedures-Surgical (ASERNIP-S), Royal Australasian College of Surgeons, Stepney, South Australia, Australia
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  • Guy J. Maddern FRACS, PhD

    Corresponding author
    1. Australian Safety and Efficacy Register of New Interventional Procedures-Surgical (ASERNIP-S), Royal Australasian College of Surgeons, Stepney, South Australia, Australia
    2. Discipline of Surgery, University of Adelaide, Adelaide, South Australia, Australia
    3. Department of Surgery, The Queen Elizabeth Hospital, Woodville, South Australia, Australia
    • Australian Safety and Efficacy Register of New Interventional Procedures-Surgical (ASERNIP-S), Royal Australasian College of Surgeons, PO Box 553, Stepney, South Australia, 5069, Australia
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    • Guy J. Maddern, as corresponding author, had full access to all the data in the study and had final responsibility for the decision to submit for publication.


  • Potential conflict of interest: The authors report no conflicts of interest. The authors have no financial disclosures to make.

Abstract

Deep brain stimulation (DBS) is a neurosurgical treatment, which has proven useful in treating Parkinson's disease. This systematic review assessed the safety and effectiveness of DBS for another movement disorder, essential tremor. All studies concerning the use of DBS in patients with essential tremor were identified through searching of electronic databases and hand searching of reference lists. Studies were categorized as before/after DBS or DBS stimulation on/off to allow the effect of the stimulation to be analyzed separately to that of the surgery itself. A total of 430 patients who had received DBS for essential tremor were identified. Most of the reported adverse events were mild and could be treated through changing the stimulation settings. Generally, in all studies, there was a significant improvement in outcomes after DBS compared with baseline scores. In addition, DBS was significantly better in testing when the stimulation was turned on, compared with stimulation turned off or baseline. Based on Level IV evidence, DBS is possibly a safe and effective therapy for essential tremor. © 2010 Movement Disorders Society

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