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Staging of α-synuclein in the olfactory bulb in a model of Parkinson's disease: Cell types involved

Authors

  • Isabel Ubeda-Bañon MSc,

    1. Laboratorio de Neuroanatomía Humana, Departamento de Ciencias Médicas, Facultad de Medicina, Centro Regional de Investigaciones Biomédicas, Universidad de Castilla-La Mancha, Spain
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  • Daniel Saiz-Sanchez BSc,

    1. Laboratorio de Neuroanatomía Humana, Departamento de Ciencias Médicas, Facultad de Medicina, Centro Regional de Investigaciones Biomédicas, Universidad de Castilla-La Mancha, Spain
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  • Carlos de la Rosa-Prieto MSc,

    1. Laboratorio de Neuroanatomía Humana, Departamento de Ciencias Médicas, Facultad de Medicina, Centro Regional de Investigaciones Biomédicas, Universidad de Castilla-La Mancha, Spain
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  • Alicia Mohedano-Moriano PhD,

    1. Laboratorio de Neuroanatomía Humana, Departamento de Ciencias Médicas, Facultad de Medicina, Centro Regional de Investigaciones Biomédicas, Universidad de Castilla-La Mancha, Spain
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  • Noelia Fradejas MSc,

    1. Laboratorio de Glia e Isquemia, Departamento de Ciencias Médicas, Facultad de Medicina, Universidad de Castilla-La Mancha, Spain
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  • Soledad Calvo MD, PhD,

    1. Laboratorio de Glia e Isquemia, Departamento de Ciencias Médicas, Facultad de Medicina, Universidad de Castilla-La Mancha, Spain
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  • Lucia Argandoña-Palacios MD,

    1. Complejo Hospitalario Universitario de Albacete, Servicio de Neurología, Spain
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  • Susana Garcia-Muñozguren MD,

    1. Complejo Hospitalario Universitario de Albacete, Servicio de Neurología, Spain
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  • Alino Martinez-Marcos PhD

    Corresponding author
    1. Laboratorio de Neuroanatomía Humana, Departamento de Ciencias Médicas, Facultad de Medicina, Centro Regional de Investigaciones Biomédicas, Universidad de Castilla-La Mancha, Spain
    • Dpto. CC. Médicas, Fac. Medicina, Univ. Castilla-La Mancha, Avda. Almansa 14, 02006 Albacete, Spain
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  • Potential conflict of interest: This funding does not constitute conflict of interest for any co-author.

Abstract

Impaired olfaction is an early symptom of Parkinson's disease. The underlying neuropathology likely includes α-synucleinopathy in the olfactory bulb at an earlier stage (Braak's stage1) than pathology in the substantia nigra, which is not observed until stage 3. In this report, we investigated the distribution and cell types affected by α-synuclein in the olfactory bulb of transgenic mice (2–8 months of age) expressing the human A53T variant of α-synuclein. α-Synuclein immunostaining progressively affects interneurons and mitral cells. Double labeling studies demonstrate that dopaminergic cells are hardly involved, whereas glutamatergic- and calcium binding protein-positive cells are severely affected. This temporal evolution and the cell types expressing α-synuclein are reminiscent of idiopathic Parkinson's disease and support the usefulness of this model to address specific topics in the premotor phase of the disease. © 2010 Movement Disorder Society

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