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Restless legs syndrome and Parkinson's disease in men

Authors

  • Xiang Gao MD, PhD,

    Corresponding author
    1. Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts, USA
    2. Department of Nutrition, Harvard University School of Public Health, Boston, Massachusetts, USA
    • Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, 181 Longwood Ave, Boston, MA

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  • Michael A. Schwarzschild MD, PhD,

    1. Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA
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  • Eilis J. O'Reilly ScD,

    1. Department of Nutrition, Harvard University School of Public Health, Boston, Massachusetts, USA
    2. Department of Epidemiology, Harvard University School of Public Health, Boston, Massachusetts, USA
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  • Hao Wang MD, PhD,

    1. Department of Nutrition, Harvard University School of Public Health, Boston, Massachusetts, USA
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  • Alberto Ascherio MD, DrPH

    1. Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts, USA
    2. Department of Nutrition, Harvard University School of Public Health, Boston, Massachusetts, USA
    3. Department of Epidemiology, Harvard University School of Public Health, Boston, Massachusetts, USA
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  • Potential conflict of interest: Nothing to report.

Abstract

We examined whether men with restless legs syndrome (RLS) have a higher prevalence of Parkinson's disease (PD) among 23,119 US participants of the Health Professional Follow-up Study who were free of diabetes and arthritis. RLS was assessed using a set of standardized questions recommended by the International RLS Study Group. PD cases were identified by self-reported questionnaires and confirmed by review of medical records. Compared to men without RLS, multivariate-adjusted odds ratios for PD were 1.1 (95% confidence interval: 0.4, 3.0) for men with RLS symptoms 5–14 times per month and 3.09 (95% confidence interval: 1.5, 6.2; P trend = 0.003) for those with symptoms 15 times or more per month, after adjusting for age, smoking, use of antidepressant, and other covariates. In conclusion, men with RLS are more likely to have concurrent PD. Prospective studies are warranted to clarify the temporal relationship between RLS and PD. © 2010 Movement Disorder Society

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