Potential conflict of interest: The authors report no financial support and no conflicts of interest.
Restless legs syndrome in patients with amyotrophic lateral sclerosis†
Article first published online: 10 NOV 2010
Copyright © 2010 Movement Disorder Society
Volume 25, Issue 15, pages 2658–2661, 15 November 2010
How to Cite
Lo Coco, D., Piccoli, F. and La Bella, V. (2010), Restless legs syndrome in patients with amyotrophic lateral sclerosis . Mov. Disord., 25: 2658–2661. doi: 10.1002/mds.23261
- Issue published online: 10 NOV 2010
- Article first published online: 10 NOV 2010
- Manuscript Accepted: 25 APR 2010
- Manuscript Revised: 9 MAR 2010
- Manuscript Received: 9 JAN 2010
- restless legs syndrome;
- amyotrophic lateral sclerosis;
- neurodegenerative disease;
We aimed to evaluate the frequency and determinants of restless legs syndrome (RLS) in a group of 76 patients with amyotrophic lateral sclerosis (ALS) and 100 control subjects. A diagnosis of RLS was made according to the criteria of the International RLS Study Group, and severity was assessed by the RLS severity scale. RLS was significantly more frequent in patients with ALS (ALS/RLS+) than in control subjects (25% vs. 8%; P = 0.002). Compared with control subjects, patients with ALS/RLS+ showed shorter history of RLS complaints and higher frequency of symptoms occurrence. Moreover, compared with those without RLS, patients with ALS/RLS+ showed increased functional impairment and more often reported sleep complaints. Multivariate logistic regression confirmed the association between RLS and functional impairment. Our findings suggest that RLS should be considered as a possible cause of disrupted sleep in patients with ALS and should be specifically investigated in these patients. © 2010 Movement Disorder Society.