Get access

Progressive parkinsonism, oculomotor abnormalities and autonomic dysfunction: Clinicopathological case

Authors

  • Giovanni Fabbrini MD,

    1. Department of Neurological Sciences and Neuromed Institute, Sapienza University of Rome, Italy
    Search for more papers by this author
  • Marcello Merello MD,

    1. Neuroscience Department, Raul Carrea Institute for Neurological Research (FLENI), Buenos Aires, Argentina
    Search for more papers by this author
  • Andrew H. Evans MD FRACP,

    1. Department of Neurology, Royal Melbourne Hospital, Melbourne, Australia
    Search for more papers by this author
  • Andrew J. Lees MD MRCP,

    1. Institute of Neurology, Reta Lila Weston Institute of Neurological Studies, University College London, United Kingdom
    2. Queen Square Brain Bank for Neurological Disorders, University College London, United Kingdom
    Search for more papers by this author
  • Janice Holton PHD FRC (PATH),

    1. Institute of Neurology, Reta Lila Weston Institute of Neurological Studies, University College London, United Kingdom
    2. Queen Square Brain Bank for Neurological Disorders, University College London, United Kingdom
    Search for more papers by this author
  • David R. Williams PHD FRACP

    Corresponding author
    1. Institute of Neurology, Reta Lila Weston Institute of Neurological Studies, University College London, United Kingdom
    2. Queen Square Brain Bank for Neurological Disorders, University College London, United Kingdom
    3. Faculty of Medicine (Neurosciences), Van Cleef Roet Centre for Nervous Diseases, Monash University, Melbourne, Victoria, Australia
    • Reta Lila Weston Institute of Neurological Studies, University College London, United Kingdom

    Search for more papers by this author

  • Relevant conflict of interest: Nothing to report. Full financial disclosures and author roles can be found in the online version of this article.

Abstract

A 59-year-old woman presented with asymmetric parkinsonism that was not-responsive to Levodopa therapy. She developed early falls, postural instability, and moderately severe autonomic dysfunction. Eye movement abnormalities were reported 2 years after her first symptoms, and she eventually developed anterocollis. Experts discuss the syndromal diagnosis and predict the underlying pathology. The pathological diagnosis is given and clinical learning points are considered. © 2011 Movement Disorder Society

Ancillary