Potential conflict of interest: All other authors, except Dr. Hallet, report no conflicts of interests regardless of relationship or time frame to the current research in the article.
In vivo neurochemistry of primary focal hand dystonia: A magnetic resonance spectroscopic neurometabolite profiling study at 3T†
Article first published online: 26 OCT 2010
Copyright © 2010 Movement Disorder Society
Volume 25, Issue 16, pages 2800–2808, 15 December 2010
How to Cite
Herath, P., Gallea, C., van der Veen, J. W., Horovitz, S. G. and Hallett, M. (2010), In vivo neurochemistry of primary focal hand dystonia: A magnetic resonance spectroscopic neurometabolite profiling study at 3T. Mov. Disord., 25: 2800–2808. doi: 10.1002/mds.23306
- Issue published online: 16 DEC 2010
- Article first published online: 26 OCT 2010
- Manuscript Accepted: 17 MAY 2010
- Manuscript Revised: 25 FEB 2010
- Manuscript Received: 1 NOV 2009
- magnetic resonance spectroscopy;
- gamma amino butyric acid (GABA);
- metabolic profile;
The neurochemical basis of dystonia is unknown. The purpose of this study was to assess the differences of the inhibitory neurotransmitter, gamma amino butyric acid (GABA), in the sensorimotor cortex and the basal ganglia using magnetic resonance spectroscopy with optimized GABA sensitivity. Twenty-two patients with focal hand dystonia and 22 healthy controls were studied. No significant differences in GABA were observed between the groups in either the sensorimotor cortex or in the basal ganglia. © Movement Disorder Society.