Cerebrospinal fluid tau and phosphorylated tau protein are elevated in corticobasal syndrome

Authors

  • M.B. Aerts MD,

    1. Department of Neurology, Parkinson Center Nijmegen (ParC) and Alzheimer Centre Nijmegen, and Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, The Netherlands
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  • R.A.J. Esselink MD, PhD,

    1. Department of Neurology, Parkinson Center Nijmegen (ParC) and Alzheimer Centre Nijmegen, and Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, The Netherlands
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  • B.R. Bloem MD, PhD,

    1. Department of Neurology, Parkinson Center Nijmegen (ParC) and Alzheimer Centre Nijmegen, and Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, The Netherlands
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  • M.M. Verbeek PhD, MSc

    Corresponding author
    1. Department of Neurology, Parkinson Center Nijmegen (ParC) and Alzheimer Centre Nijmegen, and Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, The Netherlands
    2. Department of Laboratory Medicine, Parkinson Center Nijmegen (ParC) and Alzheimer Centre Nijmegen, and Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, The Netherlands
    • Radboud University Nijmegen Medical Centre, Department of Neurology, 830 LGEM, PO Box 9101, 6500 HB Nijmegen, The Netherlands
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  • Potential conflict of interest: Nothing to report.

Abstract

Differentiating corticobasal syndrome (CBS) from progressive supranuclear palsy (PSP) and idiopathic Parkinson's disease (PD) can be difficult. To investigate the additional value of cerebrospinal fluid (CSF) biomarkers in the diagnostic differentiation of parkinsonism, we analyzed the CSF concentrations of total protein, lactate and brain specific proteins amyloid-β42 protein, tau protein (t-tau), and tau protein phosphorylated at Thr181 (p-tau), in CSF samples from patients with PSP (n = 21), CBS (n = 12), and PD (n = 28). CBS patients demonstrated higher concentrations of t-tau and p-tau compared with PSP and PD patients. In discriminating CBS and PD, t-tau offered the best combination of sensitivity (75%) and specificity (90.9%), followed by p-tau (sensitivity 87.5% and specificity 75%). The p-tau/t-tau ratio resulted in sensitivity of 84.2% and specificity of 66.7% in discriminating PSP and CBS. In conclusion, our results suggest that CSF parameters are of additional value in the diagnostic differentiation of CBS and PD. © 2010 Movement Disorder Society

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