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Reduced but not oxidized cerebrospinal fluid glutathione levels are lowered in Lewy body diseases

Authors

  • Walter Maetzler MD,

    Corresponding author
    1. Department of Neurodegeneration, Center of Neurology, Hertie Institute for Clinical Brain Research and German Center for Neurodegenerative Diseases, University of Tuebingen, Tuebingen, Germany
    2. Department of Geriatric Rehabilitation, Robert-Bosch-Hospital, Stuttgart, Germany
    • Department of Neurodegeneration, University of Tuebingen, Germany, Otfried Müller-Strasse 27, 72076 Tuebingen, Germany
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    • Walter Maetzler and Stefan P. Schmid contributed equally to this work.

  • Stefan P. Schmid,

    1. Department of Neurodegeneration, Center of Neurology, Hertie Institute for Clinical Brain Research and German Center for Neurodegenerative Diseases, University of Tuebingen, Tuebingen, Germany
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    • Walter Maetzler and Stefan P. Schmid contributed equally to this work.

  • Isabel Wurster MD,

    1. Department of Neurodegeneration, Center of Neurology, Hertie Institute for Clinical Brain Research and German Center for Neurodegenerative Diseases, University of Tuebingen, Tuebingen, Germany
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  • Inga Liepelt PhD,

    1. Department of Neurodegeneration, Center of Neurology, Hertie Institute for Clinical Brain Research and German Center for Neurodegenerative Diseases, University of Tuebingen, Tuebingen, Germany
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  • Alexandra Gaenslen MD,

    1. Department of Neurodegeneration, Center of Neurology, Hertie Institute for Clinical Brain Research and German Center for Neurodegenerative Diseases, University of Tuebingen, Tuebingen, Germany
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  • Thomas Gasser MD,

    1. Department of Neurodegeneration, Center of Neurology, Hertie Institute for Clinical Brain Research and German Center for Neurodegenerative Diseases, University of Tuebingen, Tuebingen, Germany
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  • Daniela Berg MD

    1. Department of Neurodegeneration, Center of Neurology, Hertie Institute for Clinical Brain Research and German Center for Neurodegenerative Diseases, University of Tuebingen, Tuebingen, Germany
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  • Potential conflict of interest: Nothing to report.

Abstract

Reduced (GSHR) but not oxidized glutathione (GSSG) has been shown to be dramatically altered in the substantia nigra (SN) of Lewy body disease (LBD) patients post mortem; but up to now, there is no convincing evidence that these changes can be monitored in vivo. We investigated GSHR and GSSG in rapidly processed cerebrospinal fluid (CSF) and plasma samples of 80 LBD and 35 control subjects and detected reduced CSF GSHR levels in LBD subjects. The reduction was negatively associated with age but not with disease-associated parameters. Plasma GSHR, CSF GSSG, and plasma GSSG levels did not significantly differ between the groups. Our findings confirm the results from neuropathologic studies, which demonstrated an alteration of the glutathione system in LBD. We hypothesize that alterations of the glutathione system occur in a very early stage of the disease or may even represent a risk marker for LBD. © 2010 Movement Disorder Society

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