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Postural instability, frontotemporal dementia, and ophthalmoplegia: Clinicopathological case

Authors

  • Francisco Cardoso MD, PhD,

    1. Movement Disorders Unit, Neurology Service, Federal University of Minas Gerais, Belo Horizonte, Brazil
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  • John Hodges MD,

    1. Prince of Wales Medical Research Institute, University of New South Wales, Sydney, Australia
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  • Andrew H. Evans MD, FRACP,

    1. Department of Neurology, Royal Melbourne Hospital, Melbourne, Australia
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  • Tamas Revesz MD, FRCPath,

    1. Reta Lila Weston Institute of Neurological Studies, University College London, United Kingdom
    2. Queen Square Brain Bank for Neurological Disorders, University College London, United Kingdom
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  • David R. Williams PhD, FRACP

    Corresponding author
    1. Reta Lila Weston Institute of Neurological Studies, University College London, United Kingdom
    2. Queen Square Brain Bank for Neurological Disorders, University College London, United Kingdom
    3. Van Cleef Roet Centre, Monash University, Melbourne, Australia
    • Van Cleef Roet Centre, Monash University (Alfred Hospital Campus), Commercial Rd, Melbourne 3004, Australia
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  • Relevant conflicts of interest/financial disclosures: Nothing to report. Full financial disclosures and author roles may be found in the online version of this article.

Abstract

A 56-year-old man presented with gait disturbance, personality change, and behavioral disturbances. He subsequently developed falls, postural instability, and axial rigidity. The cognitive problems progressed and he developed aphasia and later eye movement abnormalities. He died after 9 years of disease. Experts discuss the syndromal diagnosis and predict the underlying pathology. The pathological diagnosis is given and clinical learning points are considered. © 2011 Movement Disorder Society

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