Relevant conflicts of interest/financial disclosures: Nothing to report. Full financial disclosures and author roles can be found in the online version of this article.
Nonlinear decline of mini-mental state examination in Parkinson's disease†
Article first published online: 19 OCT 2010
Copyright © 2010 Movement Disorder Society
Volume 26, Issue 2, pages 334–337, 1 February 2011
How to Cite
Aarsland, D., Muniz, G. and Matthews, F. (2011), Nonlinear decline of mini-mental state examination in Parkinson's disease. Mov. Disord., 26: 334–337. doi: 10.1002/mds.23416
- Issue published online: 14 MAR 2011
- Article first published online: 19 OCT 2010
- Manuscript Accepted: 3 AUG 2010
- Manuscript Revised: 8 JUN 2010
- Manuscript Received: 24 MAY 2010
- Parkinson's disease;
- cognitive impairment;
The trajectory of cognitive functioning in patients with Parkinson's disease (PD) is not known. We used a random change point model to study the individual cognitive trajectory for up to 15 years in a prevalence sample of 238 PD patients, and used the mini-mental state examination (MMSE) to assess the longitudinal cognitive course. We observed that the rate of global cognitive decline was nonlinear. Following a relatively stable period, an inflection point was identified, after which the rate of decline gained momentum with an annual decline of 2.8 points on the MMSE. The course was similar in men and women. This inflection point was estimated to occur 13.3 years (95% credible interval 11.8, 13.6) after the diagnosis of PD; however, there were wide interindividual variations in the time from onset of PD to the inflection point. © 2010 Movement Disorder Society.