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Ventricular enlargement and mild cognitive impairment in early Parkinson's disease

Authors

  • Turi O. Dalaker MD,

    Corresponding author
    1. Department of Radiology, Stavanger University Hospital, Stavanger, Norway
    2. The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway
    3. Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, Buffalo, New York, USA
    • Department of Radiology, Stavanger University Hospital, PO. Box 8100, N-4068 Stavanger, Norway
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  • Robert Zivadinov MD, PhD,

    1. Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, Buffalo, New York, USA
    2. Department of Neurology, The Jacobs Neurological Institute, State University of New York at Buffalo, Buffalo, New York, USA
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  • Deepa Preeti Ramasamy MD,

    1. Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, Buffalo, New York, USA
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  • Mona K. Beyer MD, PhD,

    1. Department of Radiology, Stavanger University Hospital, Stavanger, Norway
    2. The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway
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  • Guido Alves MD, PhD,

    1. The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway
    2. Department of Neurology, Stavanger University Hospital, Stavanger, Norway
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  • Kolbjorn S. Bronnick PhD,

    1. The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway
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  • Ole-Bjorn Tysnes MD, PhD,

    1. Institute of Clinical Medicine, University of Bergen, Bergen, Norway
    2. Department of Neurology, Haukeland University Hospital, Bergen, Norway
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  • Dag Aarsland MD, PhD,

    1. Division of Psychiatry, Stavanger University Hospital, Stavanger, Norway
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  • Jan P. Larsen MD, PhD

    1. The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway
    2. Department of Neurology, Stavanger University Hospital, Stavanger, Norway
    3. Institute of Clinical Medicine, University of Bergen, Bergen, Norway
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  • Relevant conflicts of interest/financial disclosures: Nothing to report. Full financial disclosures and author roles can be found in the online version of this article.

Abstract

Mild cognitive impairment (MCI) may predict future development of dementia in Parkinson's disease (PD). We aimed to examine the extent of subcortical brain atrophy in patients with early PD with and without MCI compared to normal controls (NC). Participating in a population-based study were 43 early, drug-naïve PD patients and 41 NC. Eleven patients were classified with MCI (MCI PD) and 32 patients without (non-MCI PD). Volumetric segmentation of 3D-T1 weighted brain MRI was performed using FreeSurfer. Groups were compared applying MANCOVA corrected for total intracranial volume, age, and sex. Results showed that left inferior lateral ventricle and third ventricle volumes were significantly larger in MCI PD than in non-MCI PD and NC. Fourth ventricular size in MCI PD was significantly different from NC and highly correlated with memory performance in MCI PD patients. This suggests that cognitive dysfunction in early PD may be associated with ventricular enlargement. © 2010 Movement Disorder Society

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