LINGO1 gene analysis in Parkinson's disease phenotypes

Authors

  • Oswaldo Lorenzo-Betancor MD,

    1. Division of Neurosciences, Neurogenetics Laboratory, Center for Applied Medical Research, University of Navarra, Pamplona, Spain
    2. Department of Neurology, Clínica Universidad de Navarra, University of Navarra School of Medicine, Pamplona, Spain
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  • Lluís Samaranch PhD,

    1. Division of Neurosciences, Neurogenetics Laboratory, Center for Applied Medical Research, University of Navarra, Pamplona, Spain
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  • Elena García-Martín MD, PhD,

    1. Biochemistry and Molecular Biology, School of Biological Sciences, University of Extremadura, Badajoz, Spain
    2. RIRAAF/RETICS, Redes Temáticas de Investigación Cooperativa en Salud, Instituto de Salud Carlos III, Spain
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  • Sebastián Cervantes MD,

    1. Division of Neurosciences, Neurogenetics Laboratory, Center for Applied Medical Research, University of Navarra, Pamplona, Spain
    2. Department of Neurology, Clínica Universidad de Navarra, University of Navarra School of Medicine, Pamplona, Spain
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  • José A.G. Agúndez MD, PhD,

    1. RIRAAF/RETICS, Redes Temáticas de Investigación Cooperativa en Salud, Instituto de Salud Carlos III, Spain
    2. Department of Pharmacology, Medical School, University of Extremadura, Badajoz, Spain
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  • Félix J. Jiménez-Jiménez MD, PhD,

    1. Department of Medicine-Neurology, Hospital Príncipe de Asturias, Universidad de Alcalá, Madrid, Spain
    2. Department of Neurology, Hospital del Sureste, Arganda del Rey, Madrid, Spain
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  • Hortensia Alonso-Navarro MD, PhD,

    1. Department of Neurology, Hospital La Mancha-Centro de Alcázar de San Juan, Ciudad Real, Spain
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  • Antonio Luengo MD,

    1. Service of Neurology, Hospital Universitario La Princesa, Madrid, Spain
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  • Francisco Coria MD, PhD,

    1. Clinic for Nervous System Disorders and Service of Neurology, Hospital Universitario Son Dureta, Palma de Mallorca, Spain
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  • Elena Lorenzo BSc,

    1. Division of Neurosciences, Neurogenetics Laboratory, Center for Applied Medical Research, University of Navarra, Pamplona, Spain
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  • Jaione Irigoyen RN,

    1. Department of Neurology, Clínica Universidad de Navarra, University of Navarra School of Medicine, Pamplona, Spain
    2. CIBERNED, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Spain
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  • Pau Pastor MD, PhD,

    Corresponding author
    1. Division of Neurosciences, Neurogenetics Laboratory, Center for Applied Medical Research, University of Navarra, Pamplona, Spain
    2. Department of Neurology, Clínica Universidad de Navarra, University of Navarra School of Medicine, Pamplona, Spain
    3. CIBERNED, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Spain
    • Neurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical Research (CIMA), University of Navarra, Pío XII 55, Pamplona 31008, Spain

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  • The Iberian Parkinson's Disease Genetics Study Group Researchers


  • Potential conflict of interest: Nothing to report.

Abstract

Background: Parkinson's disease (PD) and essential tremor (ET) may share some etiopathogenic factors. A genome-wide association study has shown that LINGO1 gene variants are associated with increased risk of ET. We hypothesized that LINGO1 variants could increase susceptibility to PD. Methods: A large series of PD subjects and healthy controls were genotyped for rs9652490 and rs11856808 LINGO1 single nucleotide polymorphisms (SNPs). Results: We found an increased frequency of the rs11856808T/T genotype in PD compared with controls (odds ratio = 1.46; corrected P value = 0.02). A recessive genetic model was the best fit for rs11856808 influence on PD (recessive gene action test: corrected P value = 0.01). Stratification analysis showed that rs11856808T/T genotype frequency was higher in the tremor-dominant PD and the classical PD (C-PD) subgroups (recessive gene action test for the C-PD subgroup: corrected P value = 0.004). Discussion: Our results indicate that LINGO1 variants could increase risk of PD, specifically those presenting the non-rigid-akinetic phenotypes, which suggests that LINGO1 may have a role in the etiology of tremor in PD at least in the Spanish population. © 2010 Movement Disorder Society

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