Carsten Eggers, Deniz Kahraman, Matthias Schmidt, and Lars Timmermann contributed equally to this work.
Akinetic-rigid and tremor-dominant Parkinson's disease patients show different patterns of FP-CIT Single photon emission computed tomography†
Article first published online: 24 JAN 2011
Copyright © 2011 Movement Disorder Society
Volume 26, Issue 3, pages 416–423, 15 February 2011
How to Cite
Eggers, C., Kahraman, D., Fink, G. R., Schmidt, M. and Timmermann, L. (2011), Akinetic-rigid and tremor-dominant Parkinson's disease patients show different patterns of FP-CIT Single photon emission computed tomography. Mov. Disord., 26: 416–423. doi: 10.1002/mds.23468
Relevant conflicts of interest/financial disclosures: Nothing to report. Full financial disclosures and author roles may be found in the online version of this article.
- Issue published online: 31 MAR 2011
- Article first published online: 24 JAN 2011
- Manuscript Accepted: 13 SEP 2010
- Manuscript Revised: 20 AUG 2010
- Manuscript Received: 31 MAY 2010
- Iodine-123 fluoropropyl–carbomethoxy-3 β-single photon emission computed tomography;
- Parkinson's disease;
- visual analysis;
- Parkinson subtype
To elucidate whether Parkinson's disease subtypes show a different pattern of Iodine-123 fluoropropyl–;carbomethoxy-3 β-(FP-CIT) single photon emission computed tomography (SPECT) binding in accordance with neuropathological findings.
We analyzed a database of consecutive patients with FP-CIT scan (n = 190) over a 3-year period and identified 122 patients (50 women, 72 men, mean age 62 ± 11.1 years) with a diagnosis of idiopathic Parkinson's disease. Patient's characteristics and FP-CIT scan results were analyzed and compared for the subgroups tremor-dominant versus akinetic-rigid and equivalent type of Parkinson's disease.
The analysis of all Parkinson's disease patients showed a significant difference between the FP-CIT uptake in the subgroups tremor-dominant and akinetic-rigid. After matching these samples for age, disease duration, disease severity (Hoehn & Yahr grade, Unified Parkinson's Disease Rating Scale score), and levodopa-equivalent dose, these findings were balanced between both groups (n = 23/23) without a significant difference (P > 0.05). However, there was a clear, significant association of visually analyzed shapes of the striatum in FP-CIT SPECT and clinical Parkinson's disease subtype.
These results confirm neuropathological models for a reduced dopaminergic projection to the dorsal putamen in akinetic-rigid patients as well as the lateral putamen and caudate nucleus in tremor-dominant patients in vivo. © 2011 Movement Disorder Society