Relevant conflicts of interest/financial disclosures: None. Full financial disclosures and author roles can be found in the online version of this article.
Reduced sympathetically driven heart rate variability during sleep in Parkinson's disease: A case-control polysomnography-based study†
Article first published online: 31 JAN 2011
Copyright © 2011 Movement Disorder Society
Volume 26, Issue 2, pages 234–240, 1 February 2011
How to Cite
Sauvageot, N., Vaillant, M. and Diederich, N. J. (2011), Reduced sympathetically driven heart rate variability during sleep in Parkinson's disease: A case-control polysomnography-based study. Mov. Disord., 26: 234–240. doi: 10.1002/mds.23479
- Issue published online: 14 MAR 2011
- Article first published online: 31 JAN 2011
- Manuscript Accepted: 21 SEP 2010
- Manuscript Revised: 19 JUL 2010
- Manuscript Received: 8 APR 2010
- heart rate variability;
- Parkinson's disease;
To study heart rate variability during nocturnal sleep in idiopathic Parkinson's disease.
Retrospective study, using part of the data set accumulated in an earlier study, in which polysomnography was performed in 35 idiopathic Parkinson's disease patients under their usual medication and in 35 non-idiopathic Parkinson's disease controls, matched for age, gender, and amount of apneas/hypopneas per hour. R-R intervals were calculated separately for non-rapid eye movements and rapid eye movements sleep stages. R-R variability was analyzed for time and frequency domains. Selected variables considered were high frequency band (0.15–0.40 Hz) influenced by parasympathetic input and low frequency band (0.04–0.15 Hz) influenced by sympathetic input. Both frequency bands were considered in normalized units (low frequency and high frequency normalized units). Low frequency/high frequency ratio was calculated as an estimate of sympathicovagal balance.
All respiratory and sleep stage characteristics were similar in both groups. Low frequency normalized unit was reduced in idiopathic Parkinson's disease patients, both for non-rapid eye movements and rapid eye movements sleep (P = 0.005). Low frequency/high frequency was smaller in idiopathic Parkinson's disease for both sleep portions (P = 0.02).
Idiopathic Parkinson's disease patients show reduced sympathetic influence on heart rate variability in both non-rapid eye movements and rapid eye movements sleep stages. We speculate that these findings are a consequence of the postganglionic noradrenergic cardiac denervation found in idiopathic Parkinson's disease patients. © 2011 Movement Disorder Society