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Phenotypic spectrum of musician's dystonia: A task-specific disorder?

Authors

  • Alexander Schmidt MD, MA,

    1. Section of Clinical and Molecular Neurogenetics, University of Lüebeck, Lübeck, Germany
    2. Department of Neurology, University of Lüebeck, Lübeck, Germany
    3. Institute of Music Physiology and Musicians' Medicine, Hanover University of Music and Drama, Hanover, Germany
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  • Hans-Christian Jabusch MD,

    1. Institute of Music Physiology and Musicians' Medicine, Hanover University of Music and Drama, Hanover, Germany
    2. Institute of Musicians' Medicine, Dresden University of Music “Carl Maria von Weber”, Dresden, Germany
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  • Eckart Altenmüller MD, MA,

    1. Institute of Music Physiology and Musicians' Medicine, Hanover University of Music and Drama, Hanover, Germany
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  • Leonie Enders BSc,

    1. Institute of Music Physiology and Musicians' Medicine, Hanover University of Music and Drama, Hanover, Germany
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  • Rachel Saunders-Pullman MD, MPH,

    1. Department of Neurology, Albert Einstein College of Medicine, Bronx, New York, USA
    2. Department of Neurology, Beth Israel Medical Center, New York, New York, USA
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  • Susan B. Bressman MD,

    1. Department of Neurology, Albert Einstein College of Medicine, Bronx, New York, USA
    2. Department of Neurology, Beth Israel Medical Center, New York, New York, USA
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  • Alexander Münchau MD,

    1. Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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  • Christine Klein MD,

    Corresponding author
    1. Section of Clinical and Molecular Neurogenetics, University of Lüebeck, Lübeck, Germany
    2. Department of Neurology, University of Lüebeck, Lübeck, Germany
    • Department of Neurology, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany
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  • Johann Hagenah MD

    1. Section of Clinical and Molecular Neurogenetics, University of Lüebeck, Lübeck, Germany
    2. Department of Neurology, University of Lüebeck, Lübeck, Germany
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  • Relevant conflict of interest: Nothing to report.

Abstract

Background: Musician's dystonia (MD) is traditionally considered a sporadic and task-specific movement disorder. Methods: The phenotypic spectrum of the disorder was studied in 116 patients suffering from MD including videotaping. Results: Based on the movement disorders observed, we categorized our patients into two different groups: (i) 65 patients with isolated MD, that is only present when playing the instrument and (ii) 51 patients with MD and one or more additional features of primary dystonia independent of MD (complex MD). Patients with a positive family history of movement disorders had an increased risk to develop complex MD [odds ratio = 4.80; 95% confidence interval: 1.94–11.92; P = 0.001]. Discussion: In previous studies, we recently identified 22 relatives with different types of movement disorders in the families of 28 MD patients. Taken together, our results further support a genetic contribution to MD with a broad individual and familial phenotypic spectrum consisting of MD, other dystonias and even other, non-dystonic movement disorders. © 2010 Movement Disorder Society

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